Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV

Rachel L. Goldberg; Tess E. Peterson; Sabina A. Haberlen; Mallory D. Witt; Frank J. Palella; Jared W. Magnani; Todd T. Brown; Jordan E. Lake; Joao A.C. Lima; Matt J. Budoff; Chiadi E. Ndumele; Katherine C. Wu; Wendy S. Post

doi:10.1097/QAD.0000000000003936

Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV

Rachel L. Goldberg, Tess E. Peterson, Sabina A. Haberlen, Mallory D. Witt, Frank J. Palella, Jared W. Magnani, Todd T. Brown, Jordan E. Lake, Joao A.C. Lima, Matt J. Budoff, Chiadi E. Ndumele, Katherine C. Wu, Wendy S. Post^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: People with HIV (PWH) are at greater risk for diastolic dysfunction compared with persons without HIV (PWOH). An increase in visceral adipose tissue is common among PWH and greater visceral adipose tissue is associated with diastolic dysfunction among PWOH. We investigated associations of visceral adipose tissue, subcutaneous adipose tissue, and other fat depots with subclinical diastolic dysfunction among men with and without HIV (MWH and MWOH). Design: Cross-sectional analysis of MWH and MWOH in the Multicenter AIDS Cohort Study (MACS). Methods: Participants underwent echocardiography for diastolic dysfunction assessment and CT scanning including subcutaneous, visceral, epicardial, and liver adiposity measurements. Diastolic dysfunction was defined by characterizing heart function on antiretroviral therapy0 criteria. Odds for diastolic dysfunction with each measure of adiposity were estimated using multivariable logistic regression. Results: Among 403 participants (median age 57, 55% white, median BMI 26 kg/m²), 25% met criteria for diastolic dysfunction and 59% MWH (82% undetectable plasma HIV RNA). Greater epicardial adipose tissue area was associated with higher odds of diastolic dysfunction [odds ratio:1.54 per SD; 95%confidence interval (CI) 1.15–2.05] when adjusted for demographics, HIV serostatus, and cardiovascular risk factors. This association did not differ by HIV serostatus and persisted when excluding MWH who were not virally suppressed. Less subcutaneous adipose tissue was associated with higher odds of diastolic dysfunction. Other adipose depots were not associated with diastolic dysfunction. Conclusion: Greater epicardial adipose tissue and less subcutaneous adipose tissue were associated with diastolic dysfunction, regardless of HIV serostatus and viral suppression. Greater epicardial adipose tissue and less subcutaneous adipose tissue observed among PWH may contribute to risk for heart failure with preserved ejection fraction in this population.

Original language	English (US)
Pages (from-to)	1485-1493
Number of pages	9
Journal	AIDS
Volume	38
Issue number	10
DOIs	https://doi.org/10.1097/QAD.0000000000003936
State	Published - Aug 1 2024

Funding

The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS), now the MACS/WIHS Combined Cohort Study (MWCCS). The MACS coronary CT angiography studies are funded by National Heart Lung and Blood Institute (NHLBI) RO1 HL095129 (Post) and R01 HL125053 (Post). MWCCS (Principal Investigators) for former- MACS sites that participated in this analysis include: Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange and Elizabeth Topper), U01-HL146193; Chicago-Northwestern CRS (Steven Wolinsky, Frank Palella, and Valentina Stosor), U01-HL146240; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding NICHD, NIA, NIDCR, NIAID, NINDS, NIMH, NIDA, NINR, NCI, NIAAA, NIDCD, NIDDK, NIMHD, and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI). The authors gratefully acknowledge the contributions of the study participants and dedication of the staff at the MWCCS sites. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS), now the MACS/WIHS Combined Cohort Study (MWCCS). The MACS coronary CT angiography studies are funded by National Heart Lung and Blood Institute (NHLBI) RO1 HL095129 (Post) and R01 HL125053 (Post). MWCCS (Principal Investigators) for former- MACS sites that participated in this analysis include: Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Data Analysis and Coordination Center (Gypsyamber D\u2019Souza, Stephen Gange and Elizabeth Topper), U01-HL146193; Chicago-Northwestern CRS (Steven Wolinsky, Frank Palella, and Valentina Stosor), U01-HL146240; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding NICHD, NIA, NIDCR, NIAID, NINDS, NIMH, NIDA, NINR, NCI, NIAAA, NIDCD, NIDDK, NIMHD, and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI). The authors gratefully acknowledge the contributions of the study participants and dedication of the staff at the MWCCS sites.

Keywords

HIV
adiposity
echocardiography
epidemiology
heart failure

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAD.0000000000003936

Cite this

Goldberg, R. L., Peterson, T. E., Haberlen, S. A., Witt, M. D., Palella, F. J., Magnani, J. W., Brown, T. T., Lake, J. E., Lima, J. A. C., Budoff, M. J., Ndumele, C. E., Wu, K. C., & Post, W. S. (2024). Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV. AIDS, 38(10), 1485-1493. https://doi.org/10.1097/QAD.0000000000003936

@article{a128e085bd0643e7a25e62a9f43bb4ef,

title = "Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV",

abstract = "Background: People with HIV (PWH) are at greater risk for diastolic dysfunction compared with persons without HIV (PWOH). An increase in visceral adipose tissue is common among PWH and greater visceral adipose tissue is associated with diastolic dysfunction among PWOH. We investigated associations of visceral adipose tissue, subcutaneous adipose tissue, and other fat depots with subclinical diastolic dysfunction among men with and without HIV (MWH and MWOH). Design: Cross-sectional analysis of MWH and MWOH in the Multicenter AIDS Cohort Study (MACS). Methods: Participants underwent echocardiography for diastolic dysfunction assessment and CT scanning including subcutaneous, visceral, epicardial, and liver adiposity measurements. Diastolic dysfunction was defined by characterizing heart function on antiretroviral therapy0 criteria. Odds for diastolic dysfunction with each measure of adiposity were estimated using multivariable logistic regression. Results: Among 403 participants (median age 57, 55% white, median BMI 26 kg/m2), 25% met criteria for diastolic dysfunction and 59% MWH (82% undetectable plasma HIV RNA). Greater epicardial adipose tissue area was associated with higher odds of diastolic dysfunction [odds ratio:1.54 per SD; 95%confidence interval (CI) 1.15–2.05] when adjusted for demographics, HIV serostatus, and cardiovascular risk factors. This association did not differ by HIV serostatus and persisted when excluding MWH who were not virally suppressed. Less subcutaneous adipose tissue was associated with higher odds of diastolic dysfunction. Other adipose depots were not associated with diastolic dysfunction. Conclusion: Greater epicardial adipose tissue and less subcutaneous adipose tissue were associated with diastolic dysfunction, regardless of HIV serostatus and viral suppression. Greater epicardial adipose tissue and less subcutaneous adipose tissue observed among PWH may contribute to risk for heart failure with preserved ejection fraction in this population.",

keywords = "HIV, adiposity, echocardiography, epidemiology, heart failure",

author = "Goldberg, {Rachel L.} and Peterson, {Tess E.} and Haberlen, {Sabina A.} and Witt, {Mallory D.} and Palella, {Frank J.} and Magnani, {Jared W.} and Brown, {Todd T.} and Lake, {Jordan E.} and Lima, {Joao A.C.} and Budoff, {Matt J.} and Ndumele, {Chiadi E.} and Wu, {Katherine C.} and Post, {Wendy S.}",

year = "2024",

month = aug,

day = "1",

doi = "10.1097/QAD.0000000000003936",

language = "English (US)",

volume = "38",

pages = "1485--1493",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

Goldberg, RL, Peterson, TE, Haberlen, SA, Witt, MD, Palella, FJ, Magnani, JW, Brown, TT, Lake, JE, Lima, JAC, Budoff, MJ, Ndumele, CE, Wu, KC & Post, WS 2024, 'Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV', AIDS, vol. 38, no. 10, pp. 1485-1493. https://doi.org/10.1097/QAD.0000000000003936

TY - JOUR

T1 - Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV

AU - Goldberg, Rachel L.

AU - Peterson, Tess E.

AU - Haberlen, Sabina A.

AU - Witt, Mallory D.

AU - Palella, Frank J.

AU - Magnani, Jared W.

AU - Brown, Todd T.

AU - Lake, Jordan E.

AU - Lima, Joao A.C.

AU - Budoff, Matt J.

AU - Ndumele, Chiadi E.

AU - Wu, Katherine C.

AU - Post, Wendy S.

PY - 2024/8/1

Y1 - 2024/8/1

N2 - Background: People with HIV (PWH) are at greater risk for diastolic dysfunction compared with persons without HIV (PWOH). An increase in visceral adipose tissue is common among PWH and greater visceral adipose tissue is associated with diastolic dysfunction among PWOH. We investigated associations of visceral adipose tissue, subcutaneous adipose tissue, and other fat depots with subclinical diastolic dysfunction among men with and without HIV (MWH and MWOH). Design: Cross-sectional analysis of MWH and MWOH in the Multicenter AIDS Cohort Study (MACS). Methods: Participants underwent echocardiography for diastolic dysfunction assessment and CT scanning including subcutaneous, visceral, epicardial, and liver adiposity measurements. Diastolic dysfunction was defined by characterizing heart function on antiretroviral therapy0 criteria. Odds for diastolic dysfunction with each measure of adiposity were estimated using multivariable logistic regression. Results: Among 403 participants (median age 57, 55% white, median BMI 26 kg/m2), 25% met criteria for diastolic dysfunction and 59% MWH (82% undetectable plasma HIV RNA). Greater epicardial adipose tissue area was associated with higher odds of diastolic dysfunction [odds ratio:1.54 per SD; 95%confidence interval (CI) 1.15–2.05] when adjusted for demographics, HIV serostatus, and cardiovascular risk factors. This association did not differ by HIV serostatus and persisted when excluding MWH who were not virally suppressed. Less subcutaneous adipose tissue was associated with higher odds of diastolic dysfunction. Other adipose depots were not associated with diastolic dysfunction. Conclusion: Greater epicardial adipose tissue and less subcutaneous adipose tissue were associated with diastolic dysfunction, regardless of HIV serostatus and viral suppression. Greater epicardial adipose tissue and less subcutaneous adipose tissue observed among PWH may contribute to risk for heart failure with preserved ejection fraction in this population.

AB - Background: People with HIV (PWH) are at greater risk for diastolic dysfunction compared with persons without HIV (PWOH). An increase in visceral adipose tissue is common among PWH and greater visceral adipose tissue is associated with diastolic dysfunction among PWOH. We investigated associations of visceral adipose tissue, subcutaneous adipose tissue, and other fat depots with subclinical diastolic dysfunction among men with and without HIV (MWH and MWOH). Design: Cross-sectional analysis of MWH and MWOH in the Multicenter AIDS Cohort Study (MACS). Methods: Participants underwent echocardiography for diastolic dysfunction assessment and CT scanning including subcutaneous, visceral, epicardial, and liver adiposity measurements. Diastolic dysfunction was defined by characterizing heart function on antiretroviral therapy0 criteria. Odds for diastolic dysfunction with each measure of adiposity were estimated using multivariable logistic regression. Results: Among 403 participants (median age 57, 55% white, median BMI 26 kg/m2), 25% met criteria for diastolic dysfunction and 59% MWH (82% undetectable plasma HIV RNA). Greater epicardial adipose tissue area was associated with higher odds of diastolic dysfunction [odds ratio:1.54 per SD; 95%confidence interval (CI) 1.15–2.05] when adjusted for demographics, HIV serostatus, and cardiovascular risk factors. This association did not differ by HIV serostatus and persisted when excluding MWH who were not virally suppressed. Less subcutaneous adipose tissue was associated with higher odds of diastolic dysfunction. Other adipose depots were not associated with diastolic dysfunction. Conclusion: Greater epicardial adipose tissue and less subcutaneous adipose tissue were associated with diastolic dysfunction, regardless of HIV serostatus and viral suppression. Greater epicardial adipose tissue and less subcutaneous adipose tissue observed among PWH may contribute to risk for heart failure with preserved ejection fraction in this population.

KW - HIV

KW - adiposity

KW - echocardiography

KW - epidemiology

KW - heart failure

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UR - http://www.scopus.com/inward/citedby.url?scp=85198633956&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000003936

DO - 10.1097/QAD.0000000000003936

M3 - Article

C2 - 38788204

AN - SCOPUS:85198633956

SN - 0269-9370

VL - 38

SP - 1485

EP - 1493

JO - AIDS

JF - AIDS

IS - 10

ER -

Associations between epicardial, visceral, and subcutaneous adipose tissue with diastolic function in men with and without HIV

Abstract

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ASJC Scopus subject areas

UN SDGs

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