Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Brian T. Joyce*, Xuefen Chen, Tao Gao, Yinan Zheng, Drew R. Nannini, Lei Liu, Benjamin E. Henkle, Ravi Kalhan, George Washko, Ken M. Kunisaki, Bharat Thyagarajan, Douglas E. Vaughan, Myron Gross, David R. Jacobs, Donald Lloyd-Jones, Lifang Hou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

Original languageEnglish (US)
Pages (from-to)693-703
Number of pages11
JournalEpigenomics
Volume15
Issue number13
DOIs
StatePublished - Jul 1 2023

Keywords

  • DNA methylation age
  • aging
  • emphysema
  • lung function
  • methylation

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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