Associations between lower extremity ischemia, upper and lower extremity strength, and functional impairment with peripheral arterial disease

Mary M. McDermott, Lu Tian, Luigi Ferrucci, Kiang Liu, Jack M. Guralnik, Yihua Liao, William H. Pearce, Michael H. Criqui

Research output: Contribution to journalArticle

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OBJECTIVES: To identify associations between lower extremity ischemia and leg strength, leg power, and hand grip in persons with and without lower extremity peripheral arterial disease (PAD). To determine whether poorer strength may mediate poorer lower extremity performance in persons with lower arterial brachial index (ABI) levels. DESIGN: Cross-sectional. SETTING: Academic medical centers. PARTICIPANTS: Four hundred twenty-four persons with PAD and 271 without PAD. MEASUREMENTS: Isometric knee extension and plantarflexion strength and handgrip strength were measured using a computer-linked strength chair. Knee extension power was measured using the Nottingham leg rig. ABI, 6-minute walk, and usual and fastest 4-m walking velocity were measured. Results were adjusted for potential confounders. RESULTS: Lower ABI values were associated with lower plantarflexion strength (P trend=.04) and lower knee extension power (P trend

Original languageEnglish (US)
Pages (from-to)724-729
Number of pages6
JournalJournal of the American Geriatrics Society
Issue number4
StatePublished - Apr 1 2008



  • Intermittent claudication
  • Limb ischemia
  • Limb strength
  • Peripheral arterial disease
  • Physical functioning

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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