Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population

Vijay A. Mittal*, Derek J. Dean, Andrea Pelletier, Michael Caligiuri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spontaneous dyskinetic movements are linked to specific pathogenic factors underlying schizophrenia, but to date there has been little research directed towards determining whether these events are associated with PLEs. In this study, 119 individuals were assessed for PLEs and administered with a sensitive instrumental test of upper extremity dyskinesia. Present findings suggest a relationship between subtle dyskinesia and PLEs in the general population, and provide a new perspective of the psychosis continuum by indicating that basal ganglia pathology may also underlie PLEs at the non-clinical end of this spectrum.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalSchizophrenia Research
Volume132
Issue number2-3
DOIs
StatePublished - Nov 2011

Keywords

  • ADAPT
  • Dyskinesia
  • Movement abnormalities
  • Psychotic-like experiences

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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