TY - JOUR
T1 - Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population
AU - Mittal, Vijay A.
AU - Dean, Derek J.
AU - Pelletier, Andrea
AU - Caligiuri, Michael
N1 - Funding Information:
This work was supported by National Institutes of Health Grants R01MH094650 and MH087258-01 to Dr. Mittal.
PY - 2011/11
Y1 - 2011/11
N2 - An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spontaneous dyskinetic movements are linked to specific pathogenic factors underlying schizophrenia, but to date there has been little research directed towards determining whether these events are associated with PLEs. In this study, 119 individuals were assessed for PLEs and administered with a sensitive instrumental test of upper extremity dyskinesia. Present findings suggest a relationship between subtle dyskinesia and PLEs in the general population, and provide a new perspective of the psychosis continuum by indicating that basal ganglia pathology may also underlie PLEs at the non-clinical end of this spectrum.
AB - An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spontaneous dyskinetic movements are linked to specific pathogenic factors underlying schizophrenia, but to date there has been little research directed towards determining whether these events are associated with PLEs. In this study, 119 individuals were assessed for PLEs and administered with a sensitive instrumental test of upper extremity dyskinesia. Present findings suggest a relationship between subtle dyskinesia and PLEs in the general population, and provide a new perspective of the psychosis continuum by indicating that basal ganglia pathology may also underlie PLEs at the non-clinical end of this spectrum.
KW - ADAPT
KW - Dyskinesia
KW - Movement abnormalities
KW - Psychotic-like experiences
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U2 - 10.1016/j.schres.2011.06.028
DO - 10.1016/j.schres.2011.06.028
M3 - Article
C2 - 21782390
AN - SCOPUS:80054052127
SN - 0920-9964
VL - 132
SP - 194
EP - 196
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -
