Associations of α- and γ-tocopherol during early life with lung function in childhood

Rajesh Kumar; Ryan P. Ferrie; Lauren C. Balmert; Matthew Kienzl; Sheryl L. Rifas-Shiman; Diane R. Gold; Joanne E. Sordillo; Ken Kleinman; Carlos A. Camargo; Augusto A. Litonjua; Emily Oken; Joan M Cook-Mills

doi:10.1016/j.jaci.2020.04.019

Associations of α- and γ-tocopherol during early life with lung function in childhood

Rajesh Kumar, Ryan P. Ferrie, Lauren C. Balmert, Matthew Kienzl, Sheryl L. Rifas-Shiman, Diane R. Gold, Joanne E. Sordillo, Ken Kleinman, Carlos A. Camargo, Augusto A. Litonjua, Emily Oken, Joan M Cook-Mills^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Tocopherol isoforms may regulate child lung growth and spirometric measures. Objective: Our aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function. Methods: We included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM_2.5) particulate exposure) stratified by tertiles of child γ-T level were used to assess the association of α-T levels with FEV₁ and forced vital capacity (FVC) percent predicted. Similarly, models stratified by child α-T tertile evaluated associations of γ-T levels with lung function. We performed similar analyses with maternal second trimester tocopherol isoform levels. Results: The median maternal second trimester α-T level was 63 μM (interquartile range = 47-82). The median early-childhood level was 25 μM (interquartile range = 20-33 μM). In the lowest tertile of early-childhood γ-T, children with a higher α-T level (per 10 μM) had a higher mid-childhood FEV₁ percent predicted (β = 3.09; 95% CI = 0.58-5.59 and a higher FVC percent predicted (β = 2.77; 95% CI = 0.47-5.06). This protective association of α-T was lost at higher γ-T levels. We did not see any consistent associations of second trimester levels of either α-T or γ-T with mid-childhood FEV₁ or FVC. Conclusion: When γ-T levels were in the lowest tertile, a higher early-childhood α-T level was associated with better lung function at mid-childhood. Second trimester maternal plasma α-T concentration was 3-fold higher than in the adult nonpregnant female population.

Original language	English (US)
Pages (from-to)	1349-1357.e3
Journal	Journal of Allergy and Clinical Immunology
Volume	146
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2020.04.019
State	Published - Dec 2020

Keywords

Tocopherol isoforms
child
lung function

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2020.04.019

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Kumar, R., Ferrie, R. P., Balmert, L. C., Kienzl, M., Rifas-Shiman, S. L., Gold, D. R., Sordillo, J. E., Kleinman, K., Camargo, C. A., Litonjua, A. A., Oken, E., & Cook-Mills, J. M. (2020). Associations of α- and γ-tocopherol during early life with lung function in childhood. Journal of Allergy and Clinical Immunology, 146(6), 1349-1357.e3. https://doi.org/10.1016/j.jaci.2020.04.019

@article{9ccf1a2a6b7249888e086bb5944adb10,

title = "Associations of α- and γ-tocopherol during early life with lung function in childhood",

abstract = "Background: Tocopherol isoforms may regulate child lung growth and spirometric measures. Objective: Our aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function. Methods: We included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM2.5) particulate exposure) stratified by tertiles of child γ-T level were used to assess the association of α-T levels with FEV1 and forced vital capacity (FVC) percent predicted. Similarly, models stratified by child α-T tertile evaluated associations of γ-T levels with lung function. We performed similar analyses with maternal second trimester tocopherol isoform levels. Results: The median maternal second trimester α-T level was 63 μM (interquartile range = 47-82). The median early-childhood level was 25 μM (interquartile range = 20-33 μM). In the lowest tertile of early-childhood γ-T, children with a higher α-T level (per 10 μM) had a higher mid-childhood FEV1 percent predicted (β = 3.09; 95% CI = 0.58-5.59 and a higher FVC percent predicted (β = 2.77; 95% CI = 0.47-5.06). This protective association of α-T was lost at higher γ-T levels. We did not see any consistent associations of second trimester levels of either α-T or γ-T with mid-childhood FEV1 or FVC. Conclusion: When γ-T levels were in the lowest tertile, a higher early-childhood α-T level was associated with better lung function at mid-childhood. Second trimester maternal plasma α-T concentration was 3-fold higher than in the adult nonpregnant female population.",

keywords = "Tocopherol isoforms, child, lung function",

author = "Rajesh Kumar and Ferrie, {Ryan P.} and Balmert, {Lauren C.} and Matthew Kienzl and Rifas-Shiman, {Sheryl L.} and Gold, {Diane R.} and Sordillo, {Joanne E.} and Ken Kleinman and Camargo, {Carlos A.} and Litonjua, {Augusto A.} and Emily Oken and Cook-Mills, {Joan M}",

note = "Funding Information: J. M. Cook-Mills was supported by National Institutes of Health (NIH) grant R01AI127695, United States . R. Kumar was supported by NIH grant R01AI127695 , as well as by grants HHSN2752011300013C , U19AR06952 , and UG1HL139125, United States . Project Viva is supported by grants R01HD034568 , R01AI102960 , and UH3OD023286, United States . Publisher Copyright: {\textcopyright} 2020 American Academy of Allergy, Asthma & Immunology",

year = "2020",

month = dec,

doi = "10.1016/j.jaci.2020.04.019",

language = "English (US)",

volume = "146",

pages = "1349--1357.e3",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "6",

}

Kumar, R, Ferrie, RP, Balmert, LC, Kienzl, M, Rifas-Shiman, SL, Gold, DR, Sordillo, JE, Kleinman, K, Camargo, CA, Litonjua, AA, Oken, E & Cook-Mills, JM 2020, 'Associations of α- and γ-tocopherol during early life with lung function in childhood', Journal of Allergy and Clinical Immunology, vol. 146, no. 6, pp. 1349-1357.e3. https://doi.org/10.1016/j.jaci.2020.04.019

TY - JOUR

T1 - Associations of α- and γ-tocopherol during early life with lung function in childhood

AU - Kumar, Rajesh

AU - Ferrie, Ryan P.

AU - Balmert, Lauren C.

AU - Kienzl, Matthew

AU - Rifas-Shiman, Sheryl L.

AU - Gold, Diane R.

AU - Sordillo, Joanne E.

AU - Kleinman, Ken

AU - Camargo, Carlos A.

AU - Litonjua, Augusto A.

AU - Oken, Emily

AU - Cook-Mills, Joan M

N1 - Funding Information: J. M. Cook-Mills was supported by National Institutes of Health (NIH) grant R01AI127695, United States . R. Kumar was supported by NIH grant R01AI127695 , as well as by grants HHSN2752011300013C , U19AR06952 , and UG1HL139125, United States . Project Viva is supported by grants R01HD034568 , R01AI102960 , and UH3OD023286, United States . Publisher Copyright: © 2020 American Academy of Allergy, Asthma & Immunology

PY - 2020/12

Y1 - 2020/12

N2 - Background: Tocopherol isoforms may regulate child lung growth and spirometric measures. Objective: Our aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function. Methods: We included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM2.5) particulate exposure) stratified by tertiles of child γ-T level were used to assess the association of α-T levels with FEV1 and forced vital capacity (FVC) percent predicted. Similarly, models stratified by child α-T tertile evaluated associations of γ-T levels with lung function. We performed similar analyses with maternal second trimester tocopherol isoform levels. Results: The median maternal second trimester α-T level was 63 μM (interquartile range = 47-82). The median early-childhood level was 25 μM (interquartile range = 20-33 μM). In the lowest tertile of early-childhood γ-T, children with a higher α-T level (per 10 μM) had a higher mid-childhood FEV1 percent predicted (β = 3.09; 95% CI = 0.58-5.59 and a higher FVC percent predicted (β = 2.77; 95% CI = 0.47-5.06). This protective association of α-T was lost at higher γ-T levels. We did not see any consistent associations of second trimester levels of either α-T or γ-T with mid-childhood FEV1 or FVC. Conclusion: When γ-T levels were in the lowest tertile, a higher early-childhood α-T level was associated with better lung function at mid-childhood. Second trimester maternal plasma α-T concentration was 3-fold higher than in the adult nonpregnant female population.

AB - Background: Tocopherol isoforms may regulate child lung growth and spirometric measures. Objective: Our aim was to determine the extent to which plasma α-tocopherol (α-T) or γ-tocopherol (γ-T) isoform levels in early childhood or in utero are associated with childhood lung function. Methods: We included 622 participants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years). Maternal and child tocopherol isoform levels were measured by HPLC at the second trimester and 3 years of age, respectively. Multivariable linear regression models (adjusted for mid-childhood body mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter with diameter of <2.5 micrometers (PM2.5) particulate exposure) stratified by tertiles of child γ-T level were used to assess the association of α-T levels with FEV1 and forced vital capacity (FVC) percent predicted. Similarly, models stratified by child α-T tertile evaluated associations of γ-T levels with lung function. We performed similar analyses with maternal second trimester tocopherol isoform levels. Results: The median maternal second trimester α-T level was 63 μM (interquartile range = 47-82). The median early-childhood level was 25 μM (interquartile range = 20-33 μM). In the lowest tertile of early-childhood γ-T, children with a higher α-T level (per 10 μM) had a higher mid-childhood FEV1 percent predicted (β = 3.09; 95% CI = 0.58-5.59 and a higher FVC percent predicted (β = 2.77; 95% CI = 0.47-5.06). This protective association of α-T was lost at higher γ-T levels. We did not see any consistent associations of second trimester levels of either α-T or γ-T with mid-childhood FEV1 or FVC. Conclusion: When γ-T levels were in the lowest tertile, a higher early-childhood α-T level was associated with better lung function at mid-childhood. Second trimester maternal plasma α-T concentration was 3-fold higher than in the adult nonpregnant female population.

KW - Tocopherol isoforms

KW - child

KW - lung function

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U2 - 10.1016/j.jaci.2020.04.019

DO - 10.1016/j.jaci.2020.04.019

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SP - 1349-1357.e3

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 6

ER -

Associations of α- and γ-tocopherol during early life with lung function in childhood

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