Associations of androgens with physical activity and fitness in young black and white men: The CARDIA Male Hormone Study

Kathleen Y. Wolin; Laura A. Colangelo; Kiang Liu; Barbara Sternfeld; Susan M. Gapstur

doi:10.1016/j.ypmed.2006.12.004

Associations of androgens with physical activity and fitness in young black and white men: The CARDIA Male Hormone Study

Kathleen Y. Wolin^*, Laura A. Colangelo, Kiang Liu, Barbara Sternfeld, Susan M. Gapstur

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective.: The association between physical activity or cardiovascular fitness and chronic disease risk in men might be mediated, in part, through androgens. Limited data exists on the potential associations of activity or fitness with serum hormones. We examined the associations of serum testosterone and sex hormone binding globulin (SHBG) concentrations with physical activity and cardiorespiratory fitness in black and white young men. Method.: Data were collected from 391 black and 604 white male participants of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Male Hormone Study aged 24-32 in 1992-1993. Cross-sectional associations of serum total testosterone (TT), bioavailable testosterone (BT) and SHBG levels with self-reported total physical activity score, and in a subset of men (n = 617) with cardiorespiratory fitness measured via duration on a treadmill test were assessed. Five-year longitudinal associations of change in hormones with changes in physical activity also were examined. Results.: There were no cross-sectional or longitudinal associations of physical activity with SHBG, TT or BT in either black or white men. Fitness was positively associated with SHBG only in white men, but was not associated with TT or BT in either group. Conclusion.: Overall the results do not support an association of self-reported physical activity with androgens, whereas they do suggest that fitness might be associated with SHBG in white men.

Original language	English (US)
Pages (from-to)	426-431
Number of pages	6
Journal	Preventive medicine
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.ypmed.2006.12.004
State	Published - May 2007

Funding

This research was supported by US Public Health Service grant R01-CA770403 from the National Cancer Institute, and PHS contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung, and Blood Institute. Dr. Wolin is supported by grant R25 CA100600-01A1 from the National Cancer Institute. All hormone measurements were conducted in the laboratory of the late Dr. Christopher Longcope at the University of Massachusetts, Worcester. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Keywords

Androgens
Cardiorespiratory fitness
Physical activity
Sex hormone binding globulin
Testosterone

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Epidemiology

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10.1016/j.ypmed.2006.12.004

Cite this

@article{ad3e14e6abe248fbb135fc113a234bcf,

title = "Associations of androgens with physical activity and fitness in young black and white men: The CARDIA Male Hormone Study",

abstract = "Objective.: The association between physical activity or cardiovascular fitness and chronic disease risk in men might be mediated, in part, through androgens. Limited data exists on the potential associations of activity or fitness with serum hormones. We examined the associations of serum testosterone and sex hormone binding globulin (SHBG) concentrations with physical activity and cardiorespiratory fitness in black and white young men. Method.: Data were collected from 391 black and 604 white male participants of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Male Hormone Study aged 24-32 in 1992-1993. Cross-sectional associations of serum total testosterone (TT), bioavailable testosterone (BT) and SHBG levels with self-reported total physical activity score, and in a subset of men (n = 617) with cardiorespiratory fitness measured via duration on a treadmill test were assessed. Five-year longitudinal associations of change in hormones with changes in physical activity also were examined. Results.: There were no cross-sectional or longitudinal associations of physical activity with SHBG, TT or BT in either black or white men. Fitness was positively associated with SHBG only in white men, but was not associated with TT or BT in either group. Conclusion.: Overall the results do not support an association of self-reported physical activity with androgens, whereas they do suggest that fitness might be associated with SHBG in white men.",

keywords = "Androgens, Cardiorespiratory fitness, Physical activity, Sex hormone binding globulin, Testosterone",

author = "Wolin, \{Kathleen Y.\} and Colangelo, \{Laura A.\} and Kiang Liu and Barbara Sternfeld and Gapstur, \{Susan M.\}",

note = "Funding Information: This research was supported by US Public Health Service grant R01-CA770403 from the National Cancer Institute, and PHS contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung, and Blood Institute. Dr. Wolin is supported by grant R25 CA100600-01A1 from the National Cancer Institute. All hormone measurements were conducted in the laboratory of the late Dr. Christopher Longcope at the University of Massachusetts, Worcester. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. ",

year = "2007",

month = may,

doi = "10.1016/j.ypmed.2006.12.004",

language = "English (US)",

volume = "44",

pages = "426--431",

journal = "Preventive medicine",

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T1 - Associations of androgens with physical activity and fitness in young black and white men

T2 - The CARDIA Male Hormone Study

AU - Wolin, Kathleen Y.

AU - Colangelo, Laura A.

AU - Liu, Kiang

AU - Sternfeld, Barbara

AU - Gapstur, Susan M.

N1 - Funding Information: This research was supported by US Public Health Service grant R01-CA770403 from the National Cancer Institute, and PHS contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung, and Blood Institute. Dr. Wolin is supported by grant R25 CA100600-01A1 from the National Cancer Institute. All hormone measurements were conducted in the laboratory of the late Dr. Christopher Longcope at the University of Massachusetts, Worcester. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

PY - 2007/5

Y1 - 2007/5

N2 - Objective.: The association between physical activity or cardiovascular fitness and chronic disease risk in men might be mediated, in part, through androgens. Limited data exists on the potential associations of activity or fitness with serum hormones. We examined the associations of serum testosterone and sex hormone binding globulin (SHBG) concentrations with physical activity and cardiorespiratory fitness in black and white young men. Method.: Data were collected from 391 black and 604 white male participants of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Male Hormone Study aged 24-32 in 1992-1993. Cross-sectional associations of serum total testosterone (TT), bioavailable testosterone (BT) and SHBG levels with self-reported total physical activity score, and in a subset of men (n = 617) with cardiorespiratory fitness measured via duration on a treadmill test were assessed. Five-year longitudinal associations of change in hormones with changes in physical activity also were examined. Results.: There were no cross-sectional or longitudinal associations of physical activity with SHBG, TT or BT in either black or white men. Fitness was positively associated with SHBG only in white men, but was not associated with TT or BT in either group. Conclusion.: Overall the results do not support an association of self-reported physical activity with androgens, whereas they do suggest that fitness might be associated with SHBG in white men.

AB - Objective.: The association between physical activity or cardiovascular fitness and chronic disease risk in men might be mediated, in part, through androgens. Limited data exists on the potential associations of activity or fitness with serum hormones. We examined the associations of serum testosterone and sex hormone binding globulin (SHBG) concentrations with physical activity and cardiorespiratory fitness in black and white young men. Method.: Data were collected from 391 black and 604 white male participants of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Male Hormone Study aged 24-32 in 1992-1993. Cross-sectional associations of serum total testosterone (TT), bioavailable testosterone (BT) and SHBG levels with self-reported total physical activity score, and in a subset of men (n = 617) with cardiorespiratory fitness measured via duration on a treadmill test were assessed. Five-year longitudinal associations of change in hormones with changes in physical activity also were examined. Results.: There were no cross-sectional or longitudinal associations of physical activity with SHBG, TT or BT in either black or white men. Fitness was positively associated with SHBG only in white men, but was not associated with TT or BT in either group. Conclusion.: Overall the results do not support an association of self-reported physical activity with androgens, whereas they do suggest that fitness might be associated with SHBG in white men.

KW - Androgens

KW - Cardiorespiratory fitness

KW - Physical activity

KW - Sex hormone binding globulin

KW - Testosterone

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JF - Preventive medicine

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ER -

Associations of androgens with physical activity and fitness in young black and white men: The CARDIA Male Hormone Study

Abstract

Funding

Keywords

ASJC Scopus subject areas

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