Abstract
Objective.: The association between physical activity or cardiovascular fitness and chronic disease risk in men might be mediated, in part, through androgens. Limited data exists on the potential associations of activity or fitness with serum hormones. We examined the associations of serum testosterone and sex hormone binding globulin (SHBG) concentrations with physical activity and cardiorespiratory fitness in black and white young men. Method.: Data were collected from 391 black and 604 white male participants of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Male Hormone Study aged 24-32 in 1992-1993. Cross-sectional associations of serum total testosterone (TT), bioavailable testosterone (BT) and SHBG levels with self-reported total physical activity score, and in a subset of men (n = 617) with cardiorespiratory fitness measured via duration on a treadmill test were assessed. Five-year longitudinal associations of change in hormones with changes in physical activity also were examined. Results.: There were no cross-sectional or longitudinal associations of physical activity with SHBG, TT or BT in either black or white men. Fitness was positively associated with SHBG only in white men, but was not associated with TT or BT in either group. Conclusion.: Overall the results do not support an association of self-reported physical activity with androgens, whereas they do suggest that fitness might be associated with SHBG in white men.
Original language | English (US) |
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Pages (from-to) | 426-431 |
Number of pages | 6 |
Journal | Preventive medicine |
Volume | 44 |
Issue number | 5 |
DOIs | |
State | Published - May 2007 |
Funding
This research was supported by US Public Health Service grant R01-CA770403 from the National Cancer Institute, and PHS contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and N01-HC-95095 from the National Heart, Lung, and Blood Institute. Dr. Wolin is supported by grant R25 CA100600-01A1 from the National Cancer Institute. All hormone measurements were conducted in the laboratory of the late Dr. Christopher Longcope at the University of Massachusetts, Worcester. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Keywords
- Androgens
- Cardiorespiratory fitness
- Physical activity
- Sex hormone binding globulin
- Testosterone
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Epidemiology