Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Christina M. Parrinello, Simin Hua, Mercedes R. Carnethon, Linda C. Gallo, Barry I. Hudson, Ronald B. Goldberg, Alan M. Delamater, Robert C. Kaplan, Carmen R. Isasi*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Aims We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods Among 1316 children 8–16 years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥ 48.1 and ≥ 2.02 ng/mL, respectively). Results Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p < 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

Original languageEnglish (US)
Pages (from-to)836-842
Number of pages7
JournalJournal of Diabetes and Its Complications
Volume31
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • Adolescents/children
  • E-selectin
  • Hispanics
  • Hyyperglycemia
  • Insulin resistance
  • Plasminogen activator inhibitor-1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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