Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers

Mary E. Turyk; Henry A. Anderson; Sally Freels; Robert Chatterton; Larry L. Needham; Donald G. Patterson; Dyan N. Steenport; Lynda Knobeloch; Pamela Imm; Victoria W. Persky

doi:10.1016/j.envres.2006.01.009

Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers

Mary E. Turyk^*, Henry A. Anderson, Sally Freels, Robert Chatterton, Larry L. Needham, Donald G. Patterson, Dyan N. Steenport, Lynda Knobeloch, Pamela Imm, Victoria W. Persky

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

This study investigated the relationships of steroid and thyroid hormones with total noncoplanar polychlorinated biphenyls (PCBs), total toxic equivalents (TEQs) from dioxins-like organochlorines, and dichlorodiphenyl dichloroethene (DDE) in 56 male frequent and infrequent Great Lakes sport caught fish consumers. Significant negative associations were found for triiodothyronine (T₃), thyroxine (T₄), thyroid stimulating hormone (TSH), and sex hormone binding globulin (SHBG)-bound testosterone with PCBs, for TSH with total TEQs, and for estrone sulfate with DDE, adjusting for age, body mass index, and medication use. Follicle-stimulating hormone, luteinizing hormone, free testosterone, and SHBG were not significantly associated with organochlorines. Models that accounted for exposure to both PCBs and TEQs predicted T₄, estrone sulfate, and SHBG-bound testosterone better than models that included either PCBs or TEQs alone, with the lowest hormone levels occurring in the participants with both higher PCB levels and lower TEQ levels. These data suggest that exposure to PCBs, dioxin-like organochlorines, and DDE, alone and potentially in combination, may be associated with effects on the endocrine system in adult males. Further studies should help delineate specific exposure effects and effects of exposures to other common environmental contaminants alone and in combination with PCBs.

Original language	English (US)
Pages (from-to)	299-307
Number of pages	9
Journal	Environmental Research
Volume	102
Issue number	3
DOIs	https://doi.org/10.1016/j.envres.2006.01.009
State	Published - Nov 2006

Funding

This research was funded by the Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA, Grant Number H75/ATH598322. The research and researchers were supported in part by the Center for Disease Control and Prevention (CDC) Training Program Grant # 1 T01 CD000189-01. This study was conducted in accordance with national and institutional guidelines for the protection of human subjects. Prior to initiation of this study protocol, it was reviewed and approved by both the University of Wisconsin-Madison Medical School Human Subjects Committee and University of Illinois-Chicago Internal Review Board. Informed consent was obtained from each subject prior to participation.

Keywords

Dioxin
Estrone sulfate
PCB
Testosterone
Thyroid

ASJC Scopus subject areas

Biochemistry
General Environmental Science

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10.1016/j.envres.2006.01.009

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@article{f756442b82ea4f1d9bff8badb2e1994f,

title = "Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers",

abstract = "This study investigated the relationships of steroid and thyroid hormones with total noncoplanar polychlorinated biphenyls (PCBs), total toxic equivalents (TEQs) from dioxins-like organochlorines, and dichlorodiphenyl dichloroethene (DDE) in 56 male frequent and infrequent Great Lakes sport caught fish consumers. Significant negative associations were found for triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and sex hormone binding globulin (SHBG)-bound testosterone with PCBs, for TSH with total TEQs, and for estrone sulfate with DDE, adjusting for age, body mass index, and medication use. Follicle-stimulating hormone, luteinizing hormone, free testosterone, and SHBG were not significantly associated with organochlorines. Models that accounted for exposure to both PCBs and TEQs predicted T4, estrone sulfate, and SHBG-bound testosterone better than models that included either PCBs or TEQs alone, with the lowest hormone levels occurring in the participants with both higher PCB levels and lower TEQ levels. These data suggest that exposure to PCBs, dioxin-like organochlorines, and DDE, alone and potentially in combination, may be associated with effects on the endocrine system in adult males. Further studies should help delineate specific exposure effects and effects of exposures to other common environmental contaminants alone and in combination with PCBs.",

keywords = "Dioxin, Estrone sulfate, PCB, Testosterone, Thyroid",

author = "Turyk, {Mary E.} and Anderson, {Henry A.} and Sally Freels and Robert Chatterton and Needham, {Larry L.} and Patterson, {Donald G.} and Steenport, {Dyan N.} and Lynda Knobeloch and Pamela Imm and Persky, {Victoria W.}",

note = "Funding Information: This research was funded by the Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA, Grant Number H75/ATH598322. The research and researchers were supported in part by the Center for Disease Control and Prevention (CDC) Training Program Grant # 1 T01 CD000189-01. This study was conducted in accordance with national and institutional guidelines for the protection of human subjects. Prior to initiation of this study protocol, it was reviewed and approved by both the University of Wisconsin-Madison Medical School Human Subjects Committee and University of Illinois-Chicago Internal Review Board. Informed consent was obtained from each subject prior to participation. ",

year = "2006",

month = nov,

doi = "10.1016/j.envres.2006.01.009",

language = "English (US)",

volume = "102",

pages = "299--307",

journal = "Environmental Research",

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T1 - Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers

AU - Turyk, Mary E.

AU - Anderson, Henry A.

AU - Freels, Sally

AU - Chatterton, Robert

AU - Needham, Larry L.

AU - Patterson, Donald G.

AU - Steenport, Dyan N.

AU - Knobeloch, Lynda

AU - Imm, Pamela

AU - Persky, Victoria W.

N1 - Funding Information: This research was funded by the Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA, Grant Number H75/ATH598322. The research and researchers were supported in part by the Center for Disease Control and Prevention (CDC) Training Program Grant # 1 T01 CD000189-01. This study was conducted in accordance with national and institutional guidelines for the protection of human subjects. Prior to initiation of this study protocol, it was reviewed and approved by both the University of Wisconsin-Madison Medical School Human Subjects Committee and University of Illinois-Chicago Internal Review Board. Informed consent was obtained from each subject prior to participation.

PY - 2006/11

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N2 - This study investigated the relationships of steroid and thyroid hormones with total noncoplanar polychlorinated biphenyls (PCBs), total toxic equivalents (TEQs) from dioxins-like organochlorines, and dichlorodiphenyl dichloroethene (DDE) in 56 male frequent and infrequent Great Lakes sport caught fish consumers. Significant negative associations were found for triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and sex hormone binding globulin (SHBG)-bound testosterone with PCBs, for TSH with total TEQs, and for estrone sulfate with DDE, adjusting for age, body mass index, and medication use. Follicle-stimulating hormone, luteinizing hormone, free testosterone, and SHBG were not significantly associated with organochlorines. Models that accounted for exposure to both PCBs and TEQs predicted T4, estrone sulfate, and SHBG-bound testosterone better than models that included either PCBs or TEQs alone, with the lowest hormone levels occurring in the participants with both higher PCB levels and lower TEQ levels. These data suggest that exposure to PCBs, dioxin-like organochlorines, and DDE, alone and potentially in combination, may be associated with effects on the endocrine system in adult males. Further studies should help delineate specific exposure effects and effects of exposures to other common environmental contaminants alone and in combination with PCBs.

AB - This study investigated the relationships of steroid and thyroid hormones with total noncoplanar polychlorinated biphenyls (PCBs), total toxic equivalents (TEQs) from dioxins-like organochlorines, and dichlorodiphenyl dichloroethene (DDE) in 56 male frequent and infrequent Great Lakes sport caught fish consumers. Significant negative associations were found for triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and sex hormone binding globulin (SHBG)-bound testosterone with PCBs, for TSH with total TEQs, and for estrone sulfate with DDE, adjusting for age, body mass index, and medication use. Follicle-stimulating hormone, luteinizing hormone, free testosterone, and SHBG were not significantly associated with organochlorines. Models that accounted for exposure to both PCBs and TEQs predicted T4, estrone sulfate, and SHBG-bound testosterone better than models that included either PCBs or TEQs alone, with the lowest hormone levels occurring in the participants with both higher PCB levels and lower TEQ levels. These data suggest that exposure to PCBs, dioxin-like organochlorines, and DDE, alone and potentially in combination, may be associated with effects on the endocrine system in adult males. Further studies should help delineate specific exposure effects and effects of exposures to other common environmental contaminants alone and in combination with PCBs.

KW - Dioxin

KW - Estrone sulfate

KW - PCB

KW - Testosterone

KW - Thyroid

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Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers

Abstract

Funding

Keywords

ASJC Scopus subject areas

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