Astroblastoma in childhood: Pathological and clinical analysis

Ramon Navarro, Aaron J. Reitman, Guillermo A. de Léon, Stewart Goldman, Maryanne Hoffman Marymont, Tadanori Tomita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Object: The object was to describe the clinical, radiologic, and pathologic features of astroblastomas in an unselected group of children who were treated in a single institution during an 11-year period. Methods: Eight children with astroblastomas of the brain were examined. Diagnosis was based on cell morphology, vascular attachment of the cell main process, lack of an epithelial-free surface differentiation, and poor intercellular cohesiveness. In addition to sections, tumor smears and electron microscopy were required for demonstrating or confirming such features. Conclusions: Clinical findings seem to confirm an apparent predilection of astroblastomas for younger children (median age of onset, 5 years) and the existence of two prognostically different types of tumor - well differentiated (low grade) and anaplastic (high grade). Microscopic findings suggest a closer resemblance of tumor cells to astroblasts rather than to "tanycytes" or ependymal cells. It seems, however, that anaplastic astroblasts have a tendency to evolve toward, or be associated with, less differentiated cells, either neuroepithelial or sarcomatous.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalChild's Nervous System
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2005

Keywords

  • Astroblast
  • Astroblastoma
  • Ependymoma
  • Gliomyosarcoma
  • Medullo-epithelioma
  • Tanycyte

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Astroblastoma in childhood: Pathological and clinical analysis'. Together they form a unique fingerprint.

Cite this