Asymmetric focal adhesion disassembly in motile cells

Joshua A. Broussard*, Donna J. Webb, Irina Kaverina

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

175 Scopus citations

Abstract

Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center and rear. In this review, we will present our understanding of the regulation of adhesion turnover and disassembly in various regions of the cell. Adhesion turnover involves a number of tyrosine kinases and phosphatases, most of which are engaged in FAK signaling pathways. Additionally, adhesions are regulated by tensile forces that depend on dynamic coupling with the actin cytoskeleton. The distribution of adhesion disassembly throughout a motile cell is likely coordinated by the asymmetry of the microtubule network. We present a model that suggests two stages of microtubule-driven adhesion disassembly: destabilization and detachment.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume20
Issue number1
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Cell Biology

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