A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enantioselectivity with a new tailored C1-symmetric biaryl-saturated imidazolium-derived NHC catalyst.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of the American Chemical Society|
|State||Published - Jan 8 2014|
ASJC Scopus subject areas
- Colloid and Surface Chemistry
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CCDC 957104: Experimental Crystal Structure Determination
Jang, K. P. (Creator), Hutson, G. E. (Creator), Johnston, R. C. (Creator), McCusker, E. O. (Creator), Cheong, P. H. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc113ybf, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc113ybf&sid=DataCite