AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma

E. Rivera; O. Arrieta; P. Guevara; A. Duarte-Rojo; J. Sotelo

doi:10.1054/bjoc.2001.2102

AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma

E. Rivera, O. Arrieta^*, P. Guevara, A. Duarte-Rojo, J. Sotelo

^*Corresponding author for this work

Medicine, Hepatology Division

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor.

Original language	English (US)
Pages (from-to)	1396-1399
Number of pages	4
Journal	British Journal of Cancer
Volume	85
Issue number	9
DOIs	https://doi.org/10.1054/bjoc.2001.2102
State	Published - Nov 2 2001

Keywords

Angiogenesis
Angiotensin
Brain tumour
Glioma
Losartan

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1054/bjoc.2001.2102

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title = "AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma",

abstract = "Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor.",

keywords = "Angiogenesis, Angiotensin, Brain tumour, Glioma, Losartan",

author = "E. Rivera and O. Arrieta and P. Guevara and A. Duarte-Rojo and J. Sotelo",

note = "Funding Information: The authors thank Adolfo G{\'a}rcia-S{\'a}inz MD, PhD and Daniel Rembao MD for technical advice and histopathological evaluation; and Elena Trueta MD (Merck Sharp & Dome) for providing the Losartan. This work was partly supported by the National Council of Science and Technology of Mexico (CONACyT) L0001–M9608.",

year = "2001",

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doi = "10.1054/bjoc.2001.2102",

language = "English (US)",

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T1 - AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma

AU - Rivera, E.

AU - Arrieta, O.

AU - Guevara, P.

AU - Duarte-Rojo, A.

AU - Sotelo, J.

N1 - Funding Information: The authors thank Adolfo Gárcia-Sáinz MD, PhD and Daniel Rembao MD for technical advice and histopathological evaluation; and Elena Trueta MD (Merck Sharp & Dome) for providing the Losartan. This work was partly supported by the National Council of Science and Technology of Mexico (CONACyT) L0001–M9608.

PY - 2001/11/2

Y1 - 2001/11/2

N2 - Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor.

AB - Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor.

KW - Angiogenesis

KW - Angiotensin

KW - Brain tumour

KW - Glioma

KW - Losartan

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DO - 10.1054/bjoc.2001.2102

M3 - Article

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SN - 0007-0920

VL - 85

SP - 1396

EP - 1399

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 9

ER -

AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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