Abstract
Objective: To determine if atomoxetine would improve attention impairment following traumatic brain injury (TBI). Setting: Outpatients from a free-standing, private, not-for-profit rehabilitation hospital. Population: Fifty-five adult participants with a history of a single moderate-to-severe TBI, who were at least 1 year from injury and with self-reported complaints of attention difficulties. Intervention: Atomoxetine, a selective norepinephrine re-uptake inhibitor with a primary indication for attention dosed at 40mg twice a day for 2 weeks, compared to placebo. Design: Randomized double-blind placebo controlled trial, with placebo run-in. Measures: Cognitive Drug Research (CDR), Computerized Cognitive Assessment System, Stroop Color and Word Test, Adult ADHD Self-Report Scale (ASRS-v1.1), Neurobehavioural Functioning Inventory (NFI). Results: Atomoxetine was well-tolerated by the subject sample. The use of atomoxetine by individuals with reported attention difficulty following TBI did not significantly improve scores on measures of attention, the CDR Power of Attention domain or the Stroop Interference score. In addition, no significant relationship was found between atomoxetine use and self-reported symptoms of attention or depression. Conclusion: Atomoxetine did not significantly improve performance on measures of attention among individuals post-TBI with difficulties with attention. This study follows a trend of other pharmacological studies not demonstrating significant results among those with a history of TBI. Various possibilities are discussed, including the need for a more sophisticated system of classification of TBI.
Original language | English (US) |
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Pages (from-to) | 1514-1522 |
Number of pages | 9 |
Journal | Brain Injury |
Volume | 28 |
Issue number | 12 |
DOIs | |
State | Published - Nov 1 2014 |
Funding
This research was supported by the Rocky Mountain Regional Brain Injury System (Grant number H133A070022) which was funded by an award from the US Department of Education’s National Institute on Disability and Rehabilitation Research. The contents of this publication are the opinions of the authors and do not necessarily reflect the views of the Department of Education. Additionally, this research received investigator-initiated support from Lilly Research Laboratories, who provided active drug and placebo for this project.
Keywords
- Atomoxetine
- Attention
- Cognitive drug research
- Controlled trial
- Norepinephrine
- Traumatic brain injury
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Developmental and Educational Psychology
- Clinical Neurology