Atopic Dermatitis: Beyond the Skin and Into the Gut

Rachel L. Sadowsky, Pranvera Sulejmani, Peter A. Lio*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Atopic dermatitis (AD) is a common, chronic and recurring inflammatory skin disorder characterized by an intensely pruritic, eczematous dermatitis. The etiology of AD is thought to involve a combination of environmental, genetic, and immunologic factors. Emerging research has investigated factors that may impact individual risk for developing AD, disease severity, and treatment response. One component is the gut microbiome, which is considered to play an essential role in maintaining the homeostasis of several organ systems. The gut microbiome has been described as a major regulator of the “gut–skin axis,” yet some studies have yielded conflicting evidence regarding the strength of the association of gut microbiota dysbiosis with AD. This review discusses recent insights into the role of the gut microbiome in AD pathogenesis and its interplay among other complex systems that govern the current assessments of and treatments for AD.

Original languageEnglish (US)
Article number5534
JournalJournal of Clinical Medicine
Volume12
Issue number17
DOIs
StatePublished - Sep 2023

Keywords

  • atopic dermatitis
  • gut microbiome
  • gut–skin axis

ASJC Scopus subject areas

  • General Medicine

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