Atopic Dermatitis: Epidemiology and Pathogenesis Update

Lawrence F. Eichenfield; Charles N. Ellis; Anthony J. Mancini; Amy S. Paller; Eric L. Simpson

doi:10.1016/j.sder.2012.07.002

Atopic Dermatitis: Epidemiology and Pathogenesis Update

Lawrence F. Eichenfield^*, Charles N. Ellis, Anthony J. Mancini, Amy S. Paller, Eric L. Simpson

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD.

Original language	English (US)
Pages (from-to)	S3-S5
Journal	Seminars in cutaneous medicine and surgery
Volume	31
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/j.sder.2012.07.002
State	Published - Sep 2012

Keywords

Atopic dermatitis pathogenesis
Barrier defects
Epidermal skin barrier
Filaggrin gene

ASJC Scopus subject areas

Dermatology
Surgery

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10.1016/j.sder.2012.07.002

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title = "Atopic Dermatitis: Epidemiology and Pathogenesis Update",

abstract = "The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD.",

keywords = "Atopic dermatitis pathogenesis, Barrier defects, Epidermal skin barrier, Filaggrin gene",

author = "Eichenfield, {Lawrence F.} and Ellis, {Charles N.} and Mancini, {Anthony J.} and Paller, {Amy S.} and Simpson, {Eric L.}",

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T1 - Atopic Dermatitis

T2 - Epidemiology and Pathogenesis Update

AU - Eichenfield, Lawrence F.

AU - Ellis, Charles N.

AU - Mancini, Anthony J.

AU - Paller, Amy S.

AU - Simpson, Eric L.

PY - 2012/9

Y1 - 2012/9

N2 - The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD.

AB - The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD.

KW - Atopic dermatitis pathogenesis

KW - Barrier defects

KW - Epidermal skin barrier

KW - Filaggrin gene

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SN - 1085-5629

VL - 31

SP - S3-S5

JO - Seminars in cutaneous medicine and surgery

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Atopic Dermatitis: Epidemiology and Pathogenesis Update

Abstract

Keywords

ASJC Scopus subject areas

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