Atopic profile of patients failing medical therapy for chronic rhinosinusitis

Bruce K. Tan*, Whitney Zirkle, Rakesh K. Chandra, David Lin, David B. Conley, Anju T. Peters, Leslie C. Grammer, Robert P. Schleimer, Robert C. Kern

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Background: Chronic rhinosinusitis (CRS) is an inflammatory condition of the nasal airway and paranasal sinuses that can broadly be classified into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). The relationship between CRS and atopy to inhalant allergens remains unclear. We sought to examine the presence of atopy in patients failing medical therapy for both types of CRS. The objective of this research was to analyze the frequency and distribution of allergen sensitivity in patients failing medical therapy for CRSwNP and CRSsNP in comparison to rhinitis patients without CRS and the general population. Methods: A prospectively collected database of 334 consecutive CRS patients who had surgery after failing maximal medical therapy was queried to identify those who met inclusion criteria: a sinus computed tomography (CT), an endoscopy consistent with CRS, and skin-prick testing with 24 common inhalant allergens in 8 classes at our institution (n = 125). Additionally, data from these CRS patients were compared to a group of 50 patients diagnosed with rhinitis who had similar symptoms but radiologically normal CT scans, as well as published normative population skin-prick testing data obtained from the National Health and Nutrition Examination Study III (NHANES III). The relationship between atopy, as assessed by the frequency of skin test positivity, and radiological disease severity, was assessed for several allergen classes in CRSwNP, CRSsNP and rhinitis patients. Results: One or more positive skin results were observed in 103 of 125 (82.4%) CRS patients who underwent surgery-a prevalence significantly higher than that found in the NHANES III study (p < 0.05) but not different from the rhinitis control group (36/50, 72.0%). The most prevalent positive skin test results were to dust mites and ragweed in CRSwNP, CRSsNP, and rhinitis patients. Comparing these 3 patient groups, there were no significant differences in the rates of positive skin-test results to any single allergen. However, the median number of skin test-positive results was higher in CRSwNP patients compared to CRSsNP and rhinitis patients. Consistent with other studies, we found that CRSwNP patients were more likely to be male and have concurrent asthma. Conclusion: In our series of patients failing medical therapy for CRS, we found higher rates of atopy compared with the general population but not compared with rhinitis patients. CRSwNP patients with medically refractory sinusitis were more likely to have multiple positive skin tests and asthma as compared to the general population or patients with either CRSsNP or rhinitis. Host barrier dysfunction may play a role in enabling multisensitization.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalInternational Forum of Allergy and Rhinology
Issue number2
StatePublished - Mar 2011


  • Asthma
  • Atopy
  • Chronic rhinosinusitis
  • Endoscopic sinus surgery
  • Nasal polyposis
  • Upper airway

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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