Attentional and confusional states

M. Marsel Mesulam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The term attention refers to the preferential allocation of cognitive and neural resources to events that have become behaviorally relevant. Attention is modulated by the bottom-up influence of the ascending reticular activating system and the topdown influence of association and limbic cortices. Focal lesions that interfere with the bottom-up or top-down regulation of attention, or multifocal partial lesions that interrupt multiple domain-specific processing pathways, can disrupt the attentional matrix and give rise to the acute confusional state syndrome.

Original languageEnglish (US)
Pages (from-to)128-139
Number of pages12
JournalCONTINUUM Lifelong Learning in Neurology
Issue number4
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)


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