Attentional modulation in human primary olfactory cortex

Christina Zelano*, Moustafa Bensafi, Jess Porter, Joel Mainland, Brad Johnson, Elizabeth Bremner, Christina Telles, Rehan Khan, Noam Sobel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

174 Scopus citations

Abstract

Central to the concept of attention is the fact that identical stimuli can be processed in different ways. In olfaction, attention may designate the identical flow of air through the nose as either respiration or olfactory exploration. Here we have used functional magnetic resonance imaging (fMRI) to probe this attentional mechanism in primary olfactory cortex (POC). We report a dissociation in POC that revealed attention-dependent and attention-independent subregions. Whereas a temporal subregion comprising temporal piriform cortex (PirT) responded equally across conditions, a frontal subregion comprising frontal piriform cortex (PirF) and the olfactory tubercle responded preferentially to attended sniffs as opposed to unattended sniffs. In addition, a task-specific anticipatory response occurred in the attention-dependent region only. This dissociation was consistent across two experimental designs: one focusing on sniffs of clean air, the other focusing on odor-laden sniffs. Our findings highlight the role of attention at the earliest cortical levels of olfactory processing.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalNature neuroscience
Volume8
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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