Attitudinal barriers to participation in oncology clinical trials: Factor analysis and correlates of barriers

S. Manne*, D. Kashy, T. Albrecht, Y. N. Wong, A. Lederman Flamm, Al B Benson III, S. M. Miller, Linda Fleisher, J. Buzaglo, N. Roach, M. Katz, E. Ross, M. Collins, D. Poole, S. Raivitch, D. M. Miller, T. G. Kinzy, T. Liu, N. J. Meropol

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Patient participation in cancer clinical trials is low. Little is known about attitudinal barriers to participation, particularly among patients who may be offered a trial during an imminent initial oncology consult. The aims of the present study were to confirm the presence of proposed subscales of a recently developed cancer clinical trial attitudinal barriers measure, describe the most common cancer clinical trials attitudinal barriers, and evaluate socio-demographic, medical and financial factors associated with attitudinal barriers. A total of 1256 patients completed a survey assessing demographic factors, perceived financial burden, prior trial participation and attitudinal barriers to clinical trials participation. Results of a factor analysis did not confirm the presence of the proposed four attitudinal barriers subscale/factors. Rather, a single factor represented the best fit to the data. The most highly-rated barriers were fear of side-effects, worry about health insurance and efficacy concerns. Results suggested that less educated patients, patients with non-metastatic disease, patients with no previous oncology clinical trial participation, and patients reporting greater perceived financial burden from cancer care were associated with higher barriers. These patients may need extra attention in terms of decisional support. Overall, patients with fewer personal resources (education, financial issues) report more attitudinal barriers and should be targeted for additional decisional support.

Original languageEnglish (US)
Pages (from-to)28-38
Number of pages11
JournalEuropean Journal of Cancer Care
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2015

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Statistical Factor Analysis
Clinical Trials
Patient Participation
Neoplasms
Demography
Health Insurance
Fear
Education

Keywords

  • Attitudinal barriers
  • Decision support
  • Oncology clinical trials

ASJC Scopus subject areas

  • Oncology

Cite this

Manne, S. ; Kashy, D. ; Albrecht, T. ; Wong, Y. N. ; Lederman Flamm, A. ; Benson III, Al B ; Miller, S. M. ; Fleisher, Linda ; Buzaglo, J. ; Roach, N. ; Katz, M. ; Ross, E. ; Collins, M. ; Poole, D. ; Raivitch, S. ; Miller, D. M. ; Kinzy, T. G. ; Liu, T. ; Meropol, N. J. / Attitudinal barriers to participation in oncology clinical trials : Factor analysis and correlates of barriers. In: European Journal of Cancer Care. 2015 ; Vol. 24, No. 1. pp. 28-38.
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Manne, S, Kashy, D, Albrecht, T, Wong, YN, Lederman Flamm, A, Benson III, AB, Miller, SM, Fleisher, L, Buzaglo, J, Roach, N, Katz, M, Ross, E, Collins, M, Poole, D, Raivitch, S, Miller, DM, Kinzy, TG, Liu, T & Meropol, NJ 2015, 'Attitudinal barriers to participation in oncology clinical trials: Factor analysis and correlates of barriers', European Journal of Cancer Care, vol. 24, no. 1, pp. 28-38. https://doi.org/10.1111/ecc.12180

Attitudinal barriers to participation in oncology clinical trials : Factor analysis and correlates of barriers. / Manne, S.; Kashy, D.; Albrecht, T.; Wong, Y. N.; Lederman Flamm, A.; Benson III, Al B; Miller, S. M.; Fleisher, Linda; Buzaglo, J.; Roach, N.; Katz, M.; Ross, E.; Collins, M.; Poole, D.; Raivitch, S.; Miller, D. M.; Kinzy, T. G.; Liu, T.; Meropol, N. J.

In: European Journal of Cancer Care, Vol. 24, No. 1, 01.01.2015, p. 28-38.

Research output: Contribution to journalArticle

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T1 - Attitudinal barriers to participation in oncology clinical trials

T2 - Factor analysis and correlates of barriers

AU - Manne, S.

AU - Kashy, D.

AU - Albrecht, T.

AU - Wong, Y. N.

AU - Lederman Flamm, A.

AU - Benson III, Al B

AU - Miller, S. M.

AU - Fleisher, Linda

AU - Buzaglo, J.

AU - Roach, N.

AU - Katz, M.

AU - Ross, E.

AU - Collins, M.

AU - Poole, D.

AU - Raivitch, S.

AU - Miller, D. M.

AU - Kinzy, T. G.

AU - Liu, T.

AU - Meropol, N. J.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Patient participation in cancer clinical trials is low. Little is known about attitudinal barriers to participation, particularly among patients who may be offered a trial during an imminent initial oncology consult. The aims of the present study were to confirm the presence of proposed subscales of a recently developed cancer clinical trial attitudinal barriers measure, describe the most common cancer clinical trials attitudinal barriers, and evaluate socio-demographic, medical and financial factors associated with attitudinal barriers. A total of 1256 patients completed a survey assessing demographic factors, perceived financial burden, prior trial participation and attitudinal barriers to clinical trials participation. Results of a factor analysis did not confirm the presence of the proposed four attitudinal barriers subscale/factors. Rather, a single factor represented the best fit to the data. The most highly-rated barriers were fear of side-effects, worry about health insurance and efficacy concerns. Results suggested that less educated patients, patients with non-metastatic disease, patients with no previous oncology clinical trial participation, and patients reporting greater perceived financial burden from cancer care were associated with higher barriers. These patients may need extra attention in terms of decisional support. Overall, patients with fewer personal resources (education, financial issues) report more attitudinal barriers and should be targeted for additional decisional support.

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KW - Attitudinal barriers

KW - Decision support

KW - Oncology clinical trials

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