TY - JOUR
T1 - Atypical brainstem representation of onset and formant structure of speech sounds in children with language-based learning problems
AU - Wible, Brad
AU - Nicol, Trent
AU - Kraus, Nina
N1 - Funding Information:
We thank Cynthia King, Erin Hayes, Catherine Warrier, Dan Abrams, Krista Johnson, Nicole Russo, Gabriella Musacchia, Erika Skoe, Jason Eastman, Dottie Martin, Steven Zecker, Ann Bradlow and Jim Baker. This work was supported by National Institutes of Health Grants R01 DC01510-09, T32 DC00015-17 and F31 DC04546-01. We also thank the reviewers for their extremely helpful comments.
PY - 2004/11
Y1 - 2004/11
N2 - This study investigated how the human auditory brainstem represents constituent elements of speech sounds differently in children with language-based learning problems (LP, n=11) compared to normal children (NL, n=9), especially under stress of rapid stimulation. Children were chosen for this study based on performance on measures of reading and spelling and measures of syllable discrimination. In response to the onset of the speech sound /da/, wave V-Vn of the auditory brainstem response (ABR) had a significantly shallower slope in LP children, suggesting longer duration and/or smaller amplitude. The amplitude of the frequency following response (FFR) was diminished in LP subjects over the 229-686 Hz range, which corresponds to the first formant of the/da/ stimulus, while activity at 114 Hz, representing the fundamental frequency of /da/, was no different between groups. Normal indicators of auditory peripheral integrity suggest a central, neural origin of these differences. These data suggest that poor representation of crucial components of speech sounds could contribute to difficulties with higher-level language processes.
AB - This study investigated how the human auditory brainstem represents constituent elements of speech sounds differently in children with language-based learning problems (LP, n=11) compared to normal children (NL, n=9), especially under stress of rapid stimulation. Children were chosen for this study based on performance on measures of reading and spelling and measures of syllable discrimination. In response to the onset of the speech sound /da/, wave V-Vn of the auditory brainstem response (ABR) had a significantly shallower slope in LP children, suggesting longer duration and/or smaller amplitude. The amplitude of the frequency following response (FFR) was diminished in LP subjects over the 229-686 Hz range, which corresponds to the first formant of the/da/ stimulus, while activity at 114 Hz, representing the fundamental frequency of /da/, was no different between groups. Normal indicators of auditory peripheral integrity suggest a central, neural origin of these differences. These data suggest that poor representation of crucial components of speech sounds could contribute to difficulties with higher-level language processes.
KW - Auditory brainstem response
KW - Frequency following response
KW - Reading
KW - Speech
UR - http://www.scopus.com/inward/record.url?scp=3843119692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843119692&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2004.02.002
DO - 10.1016/j.biopsycho.2004.02.002
M3 - Article
C2 - 15294388
AN - SCOPUS:3843119692
SN - 0019-493X
VL - 67
SP - 299
EP - 317
JO - Biological Psychology
JF - Biological Psychology
IS - 3
ER -