Atypical hairy cell leukemia

M. L. Wu*, H. C. Kwaan, C. L. Goolsby

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The morphologic differential diagnosis of mature B-cell neoplasms with cytoplasmic projections includes splenic lymphoma with vicious lymphocytes and hairy cell leukemia. Although the classification of hairy cell leukemia is not universally recognized, 3 variants have been described, namely, classic, variant, and Japanese variant, each of which has different clinical and immunophenotypic features. Classic hairy cell leukemia is virtually always CD11c+, CD25+, and CD103+. Variant and Japanese variant hairy cell leukemias are usually CD11c+, always CD25-, and occasionally CD103+. Each variant is characteristically CD10-. We present a case of hairy cell leukemia with a unique immunoprofile in that the cells were CD10+, CD25+, and CD103-, and we review the criteria helpful in differentiating 'hairy' B-cell neoplasms. This case empha-sizes the variability of hairy cell leukemia anti the need to correlate all clinical and pathologic data in reaching a diagnosis.

Original languageEnglish (US)
Pages (from-to)1710-1713
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number11
StatePublished - 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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