The morphologic differential diagnosis of mature B-cell neoplasms with cytoplasmic projections includes splenic lymphoma with vicious lymphocytes and hairy cell leukemia. Although the classification of hairy cell leukemia is not universally recognized, 3 variants have been described, namely, classic, variant, and Japanese variant, each of which has different clinical and immunophenotypic features. Classic hairy cell leukemia is virtually always CD11c+, CD25+, and CD103+. Variant and Japanese variant hairy cell leukemias are usually CD11c+, always CD25-, and occasionally CD103+. Each variant is characteristically CD10-. We present a case of hairy cell leukemia with a unique immunoprofile in that the cells were CD10+, CD25+, and CD103-, and we review the criteria helpful in differentiating 'hairy' B-cell neoplasms. This case empha-sizes the variability of hairy cell leukemia anti the need to correlate all clinical and pathologic data in reaching a diagnosis.
|Original language||English (US)|
|Number of pages||4|
|Journal||Archives of Pathology and Laboratory Medicine|
|State||Published - Nov 30 2000|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology