Atypical leiomyoma with features suggesting of fumarate hydratase mutation

Jian Jun Wei

doi:10.1097/PGP.0000000000000276

Atypical leiomyoma with features suggesting of fumarate hydratase mutation

Jian Jun Wei^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Individuals with germ line or somatic mutations of fumarate hydratase are predisposed to the development of leiomyomas of the skin and uterus. In this case report, we will describe the uterine smooth muscle tumors in a young patient who was originally diagnosed with ALM from a myomectomy specimen and experienced recurrence many years later. Tumor cells are diffusely immunoreactive for 2SC, suggestive of FH mutations.

Original language	English (US)
Pages (from-to)	531-536
Number of pages	6
Journal	International Journal of Gynecological Pathology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1097/PGP.0000000000000276
State	Published - Nov 1 2016

Keywords

Atypical leiomyoma
Fumarate hydratase
Recurrence

ASJC Scopus subject areas

Pathology and Forensic Medicine
Obstetrics and Gynecology

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10.1097/PGP.0000000000000276

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title = "Atypical leiomyoma with features suggesting of fumarate hydratase mutation",

abstract = "Individuals with germ line or somatic mutations of fumarate hydratase are predisposed to the development of leiomyomas of the skin and uterus. In this case report, we will describe the uterine smooth muscle tumors in a young patient who was originally diagnosed with ALM from a myomectomy specimen and experienced recurrence many years later. Tumor cells are diffusely immunoreactive for 2SC, suggestive of FH mutations.",

keywords = "Atypical leiomyoma, Fumarate hydratase, Recurrence",

author = "Wei, {Jian Jun}",

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AB - Individuals with germ line or somatic mutations of fumarate hydratase are predisposed to the development of leiomyomas of the skin and uterus. In this case report, we will describe the uterine smooth muscle tumors in a young patient who was originally diagnosed with ALM from a myomectomy specimen and experienced recurrence many years later. Tumor cells are diffusely immunoreactive for 2SC, suggestive of FH mutations.

KW - Atypical leiomyoma

KW - Fumarate hydratase

KW - Recurrence

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Atypical leiomyoma with features suggesting of fumarate hydratase mutation

Abstract

Keywords

ASJC Scopus subject areas

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