Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age

Wan Yee Teo*, Jennifer Ross, Robert J. Bollo, Wan Tew Seow, Ah Moy Tan, Seok Gu Kang, Dong Seok Kim, Xiao Nan Li, Ching C. Lau, Carrie A. Mohila, Adekunle M. Adesina, Jack M. Su

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The authors describe a series of 15 intracranial germ cell tumors (IGCTs) excluding mature teratomas; 3 cases in children younger than 3 years of age who were treated at 3 different international institutions over the course of 20 years, and 12 from a PubMed search. These tumors, with possible in utero origins, often occur in atypical locations. The clinical behavior differed significantly from these tumors' counterparts in older children. In this young age group germinoma is highly aggressive, whereas nongerminomatous germ cell tumors may be cured without radiotherapy. Ongoing genomic studies reveal insights to attain an understanding of the biology of these tumors. New treatment strategies are needed to improve outcomes for IGCTs in this age group, particularly for germinomas.

Original languageEnglish (US)
Pages (from-to)348-355
Number of pages8
JournalJournal of Neurosurgery: Pediatrics
Volume14
Issue number4
DOIs
StatePublished - Oct 1 2014

Keywords

  • Excluding mature teratoma
  • Infants
  • Intracranial germ cell tumors
  • Oncology

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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    Teo, W. Y., Ross, J., Bollo, R. J., Seow, W. T., Tan, A. M., Kang, S. G., Kim, D. S., Li, X. N., Lau, C. C., Mohila, C. A., Adesina, A. M., & Su, J. M. (2014). Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age. Journal of Neurosurgery: Pediatrics, 14(4), 348-355. https://doi.org/10.3171/2014.6.PEDS13651