Atypical Perinuclear Anti-Neutrophil Cytoplasmic Antibodies in Ocular Inflammatory Diseases

Nazanin Ebrahimiadib, Lina Ma, Bobeck S. Modjtahedi, Samaneh Davoudi, Safa Rahmani, Sarah Syeda, Andrew Stephenson, Charles Stephen Foster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: To characterize the clinical features of patients with ocular inflammatory diseases (OID) who tested positive for atypical perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA). Methods: Retrospective case series of patients with OID seen at the Massachusetts Eye Research and Surgery Institute (MERSI) from April 2014 to April 2016. Results: 813 patients were tested for ANCA with 34 patients (4%) being positive for atypical P-ANCA. Among those with positive atypical P-ANCA, the most frequent diagnoses were anterior uveitis in 62% (n = 21) followed by scleritis in 20% (n = 7). Only one patient had an episode of recurrent disease flare-up. All but one patient, who had concomitant C-ANCA seropositivity and granulomatosis with polyangiitis, had a favorable disease course with controlled inflammation using topical and/or systemic immunomodulatory therapy. Conclusion: In contrast to typical C-ANCA and P-ANCA, atypical P-ANCA seropositivity was not associated with severe vasculitis or poor prognosis in patients with the OID.

Original languageEnglish (US)
Pages (from-to)937-941
Number of pages5
JournalOcular Immunology and Inflammation
Volume27
Issue number6
DOIs
StatePublished - Jan 1 2019

Keywords

  • Anti-neutrophil cytoplasmic antibody
  • atypical ANCA
  • ocular inflammatory diseases
  • scleritis
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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