TY - JOUR
T1 - Auditory middle latency responses in the guinea pig
AU - McGee, Therese J.
AU - Özdamar, Özcan
AU - Kraus, Nina
N1 - Funding Information:
Received from the Electrophysiology Laboratory of Siegel Institute, Michael Reese Hospital and Medical Center, Chicago, Illinois. Received August 17, 1982; accepted for publication November 15, 1982. Supported in part by the Foundation for Hearing and Speech Rehabilitation, Chicago. Presented at the Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, Florida, January 18-21, I982, Address correspondence and reprint requests to Dr. McGee.
PY - 1983
Y1 - 1983
N2 - Auditory middle latency responses (latencies 6 to 50 msec in guinea pigs) were recorded from eight awake, restrained guinea pigs. Before recording, screw electrodes were implanted in the skull in a coronal plane in line with the bregma. Another electrode, which served to monitor auditory brainstem responses, was placed 1 cm posterior to the bregma. All electrodes were referenced to a lead positioned 2 cm anterior to the bregma. During the recording session, click stimuli of various repetition rates and intensity levels were delivered monaurally in a closed sound system. Auditory brainstem responses were monitored to ensure normal functioning of the peripheral auditory system. Responses from electrodes at the midline and over the temporal area ipsilateral to the stimulus ear were greatly attenuated or absent. From an electrode over the temporal area contralateral to the stimulus ear, two positive peaks occurred at latencies of approximately 12 and 27 msec. A negative trough was identified at approximately 17 msec. Latency and amplitude functions for this waveform were determined for various stimulus levels. Response amplitude increased as stimulus repetition rate was decreased. Anesthesia greatly altered waveform structure and prolonged peak latencies. These effects were more marked at stimulus repetition rates faster than 10/sec than at slower rates. Properties of the guinea pig middle latency response are compared with those previously reported for cats and humans.
AB - Auditory middle latency responses (latencies 6 to 50 msec in guinea pigs) were recorded from eight awake, restrained guinea pigs. Before recording, screw electrodes were implanted in the skull in a coronal plane in line with the bregma. Another electrode, which served to monitor auditory brainstem responses, was placed 1 cm posterior to the bregma. All electrodes were referenced to a lead positioned 2 cm anterior to the bregma. During the recording session, click stimuli of various repetition rates and intensity levels were delivered monaurally in a closed sound system. Auditory brainstem responses were monitored to ensure normal functioning of the peripheral auditory system. Responses from electrodes at the midline and over the temporal area ipsilateral to the stimulus ear were greatly attenuated or absent. From an electrode over the temporal area contralateral to the stimulus ear, two positive peaks occurred at latencies of approximately 12 and 27 msec. A negative trough was identified at approximately 17 msec. Latency and amplitude functions for this waveform were determined for various stimulus levels. Response amplitude increased as stimulus repetition rate was decreased. Anesthesia greatly altered waveform structure and prolonged peak latencies. These effects were more marked at stimulus repetition rates faster than 10/sec than at slower rates. Properties of the guinea pig middle latency response are compared with those previously reported for cats and humans.
KW - Auditory brainstem responses
KW - Auditory middle latency response
KW - Guinea pig
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U2 - 10.1016/S0196-0709(83)80013-1
DO - 10.1016/S0196-0709(83)80013-1
M3 - Article
C2 - 6673600
AN - SCOPUS:0020612562
SN - 0196-0709
VL - 4
SP - 116
EP - 122
JO - American Journal of Otolaryngology--Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology--Head and Neck Medicine and Surgery
IS - 2
ER -