Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals

Travis White-Schwoch; Albert K. Magohe; Abigail M. Fellows; Catherine C. Rieke; Brandon Vilarello; Trent Nicol; Enica R. Massawe; Ndeserua Moshi; Nina Kraus; Jay C. Buckey

doi:10.1016/j.clinph.2020.04.165

Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals

Travis White-Schwoch, Albert K. Magohe, Abigail M. Fellows, Catherine C. Rieke, Brandon Vilarello, Trent Nicol, Enica R. Massawe, Ndeserua Moshi, Nina Kraus^*, Jay C. Buckey

^*Corresponding author for this work

Communication Sciences and Disorders

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions. Methods: A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech. Results: The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups. Conclusions: Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds. Significance: The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant.

Original language	English (US)
Pages (from-to)	1827-1832
Number of pages	6
Journal	Clinical Neurophysiology
Volume	131
Issue number	8
DOIs	https://doi.org/10.1016/j.clinph.2020.04.165
State	Published - Aug 2020

Funding

Supported by NIH (DC009972) and the Knowles Hearing Center.

Keywords

Auditory neurophysiology
Auditory processing
Electrophysiology
Frequency-following response
HIV

ASJC Scopus subject areas

Sensory Systems
Neurology
Clinical Neurology
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinph.2020.04.165

Cite this

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title = "Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals",

abstract = "Objective: To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions. Methods: A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech. Results: The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups. Conclusions: Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds. Significance: The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant.",

keywords = "Auditory neurophysiology, Auditory processing, Electrophysiology, Frequency-following response, HIV",

author = "Travis White-Schwoch and Magohe, {Albert K.} and Fellows, {Abigail M.} and Rieke, {Catherine C.} and Brandon Vilarello and Trent Nicol and Massawe, {Enica R.} and Ndeserua Moshi and Nina Kraus and Buckey, {Jay C.}",

note = "Funding Information: Supported by NIH (DC009972) and the Knowles Hearing Center. Publisher Copyright: {\textcopyright} 2020 International Federation of Clinical Neurophysiology",

year = "2020",

month = aug,

doi = "10.1016/j.clinph.2020.04.165",

language = "English (US)",

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AU - White-Schwoch, Travis

AU - Magohe, Albert K.

AU - Fellows, Abigail M.

AU - Rieke, Catherine C.

AU - Vilarello, Brandon

AU - Nicol, Trent

AU - Massawe, Enica R.

AU - Moshi, Ndeserua

AU - Kraus, Nina

AU - Buckey, Jay C.

PY - 2020/8

Y1 - 2020/8

N2 - Objective: To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions. Methods: A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech. Results: The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups. Conclusions: Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds. Significance: The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant.

AB - Objective: To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions. Methods: A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech. Results: The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups. Conclusions: Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds. Significance: The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant.

KW - Auditory neurophysiology

KW - Auditory processing

KW - Electrophysiology

KW - Frequency-following response

KW - HIV

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Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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