Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: Role of dietary vitamin E

J. F. Chester, H. A. Gaissert, J. S. Ross, R. A. Malt, S. A. Weitzman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Because ulcerative colitis predisposes to colonic cancer, for determination of the effect of colitis on experimental colon carcinogenesis, rectal instillations of peptides that attract and activate neutrophils were used to induce colitis in CD-1 (ICR) BR mice receiving 20 weekly injections of the carcinogen 1,2-dimethylhydrazine [(DMH) CAS: 540-73-8]. From week 4 through week 15 of DMH injections, twice-weekly enemas of formyl-noreleucyl-leucyl-phenylalanine were given to DMH-treated mice. The effect of the antioxidant vitamin E in the diet (1,750 IU/kg diet) was studied in another group of mice treated with DMH and having colitis. Four weeks after DMH was discontinued, cancer occurred in 9 of 28 (32%) animals with DMH plus control enemas, in 22 of 29 (76%) animals with DMH plus colitis (P = .001), and in 16 of 28 (57%) animals with DMH plus colitis plus supplemental vitamin E (P = .11 compared with the group with DMH and colitis). Colitis enhances DMH-induced colonic carcinogenesis.

Original languageEnglish (US)
Pages (from-to)939-942
Number of pages4
JournalJournal of the National Cancer Institute
Volume76
Issue number5
StatePublished - Aug 6 1986

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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