Autism

G. Dawson*, Michael Andrew Murias

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Autism is characterized by impaired social behavior and a language, and a restricted range of activities. Genome scans for linkage have been conducted with coincident signal for a few specific regions. Several promising candidate genes are being investigated. Documented neuroanatomical abnormalities include enlarged cerebral volume in early childhood and gray and white matter deviations. Autopsy findings include reduced Purkinje cells in the cerebellum and decreased numbers of neurons in the amygdala. Functional brain imaging studies document abnormalities in social brain circuitry, including the fusiform gyrus, superior temporal sulcus, amygdala, and orbit-frontal regions, as well as atypical patterns of cortical connectivity.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages779-784
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

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Keywords

  • ASD
  • Autism
  • Autism spectrum disorder
  • Early diagnosis
  • Early intervention
  • FMRI
  • Genetics
  • Head circumference
  • MRI
  • Susceptibility genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dawson, G., & Murias, M. A. (2009). Autism. In Encyclopedia of Neuroscience (pp. 779-784). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00487-3