Autism

G. Dawson; Michael Andrew Murias

doi:10.1016/B978-008045046-9.00487-3

Autism

G. Dawson^*, Michael Andrew Murias

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

Autism is characterized by impaired social behavior and a language, and a restricted range of activities. Genome scans for linkage have been conducted with coincident signal for a few specific regions. Several promising candidate genes are being investigated. Documented neuroanatomical abnormalities include enlarged cerebral volume in early childhood and gray and white matter deviations. Autopsy findings include reduced Purkinje cells in the cerebellum and decreased numbers of neurons in the amygdala. Functional brain imaging studies document abnormalities in social brain circuitry, including the fusiform gyrus, superior temporal sulcus, amygdala, and orbit-frontal regions, as well as atypical patterns of cortical connectivity.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	779-784
Number of pages	6
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00487-3
State	Published - Jan 1 2009

Keywords

ASD
Autism
Autism spectrum disorder
Early diagnosis
Early intervention
FMRI
Genetics
Head circumference
MRI
Susceptibility genes

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-008045046-9.00487-3

Cite this

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AB - Autism is characterized by impaired social behavior and a language, and a restricted range of activities. Genome scans for linkage have been conducted with coincident signal for a few specific regions. Several promising candidate genes are being investigated. Documented neuroanatomical abnormalities include enlarged cerebral volume in early childhood and gray and white matter deviations. Autopsy findings include reduced Purkinje cells in the cerebellum and decreased numbers of neurons in the amygdala. Functional brain imaging studies document abnormalities in social brain circuitry, including the fusiform gyrus, superior temporal sulcus, amygdala, and orbit-frontal regions, as well as atypical patterns of cortical connectivity.

KW - ASD

KW - Autism

KW - Autism spectrum disorder

KW - Early diagnosis

KW - Early intervention

KW - FMRI

KW - Genetics

KW - Head circumference

KW - MRI

KW - Susceptibility genes

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Autism

Abstract

Keywords

ASJC Scopus subject areas

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