Autism

G. Dawson*, Michael Andrew Murias

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapter

    5 Scopus citations

    Abstract

    Autism is characterized by impaired social behavior and a language, and a restricted range of activities. Genome scans for linkage have been conducted with coincident signal for a few specific regions. Several promising candidate genes are being investigated. Documented neuroanatomical abnormalities include enlarged cerebral volume in early childhood and gray and white matter deviations. Autopsy findings include reduced Purkinje cells in the cerebellum and decreased numbers of neurons in the amygdala. Functional brain imaging studies document abnormalities in social brain circuitry, including the fusiform gyrus, superior temporal sulcus, amygdala, and orbit-frontal regions, as well as atypical patterns of cortical connectivity.

    Original languageEnglish (US)
    Title of host publicationEncyclopedia of Neuroscience
    PublisherElsevier Ltd
    Pages779-784
    Number of pages6
    ISBN (Print)9780080450469
    DOIs
    StatePublished - Jan 1 2009

    Keywords

    • ASD
    • Autism
    • Autism spectrum disorder
    • Early diagnosis
    • Early intervention
    • FMRI
    • Genetics
    • Head circumference
    • MRI
    • Susceptibility genes

    ASJC Scopus subject areas

    • Neuroscience(all)

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