Autism and Mental Retardation: Neuropathologic Studies Performed in Four Retarded Persons with Autistic Behavior

Roger S. Williams*, Stephen L. Hauser, Dominick P. Purpura, G. Robert DeLong, Charles N. Swisher

*Corresponding author for this work

Research output: Contribution to journalArticle

239 Scopus citations

Abstract

Four persons who exhibited prominent autistic features throughout life died when 4,14, 27, and 33 years old. All were mentally retarded. One had documented phenylketonuria, but the cause of mental retardation and autistic behavior was undefined in three. At the time of autopsy, brain weights were within 2 SDs of the norm for age. Complete neuropathologic examination, including analysis of cortical neurons impregnated with the rapid Golgi method, failed to provide clues as to cause or the pathoanatomic substrate of autistic behavior in these cases.

Original languageEnglish (US)
Pages (from-to)749-753
Number of pages5
JournalArchives of Neurology
Volume37
Issue number12
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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