TY - JOUR
T1 - Autism and Mental Retardation
T2 - Neuropathologic Studies Performed in Four Retarded Persons with Autistic Behavior
AU - Williams, Roger S.
AU - Hauser, Stephen L.
AU - Purpura, Dominick P.
AU - DeLong, G. Robert
AU - Swisher, Charles N.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - Four persons who exhibited prominent autistic features throughout life died when 4,14, 27, and 33 years old. All were mentally retarded. One had documented phenylketonuria, but the cause of mental retardation and autistic behavior was undefined in three. At the time of autopsy, brain weights were within 2 SDs of the norm for age. Complete neuropathologic examination, including analysis of cortical neurons impregnated with the rapid Golgi method, failed to provide clues as to cause or the pathoanatomic substrate of autistic behavior in these cases.
AB - Four persons who exhibited prominent autistic features throughout life died when 4,14, 27, and 33 years old. All were mentally retarded. One had documented phenylketonuria, but the cause of mental retardation and autistic behavior was undefined in three. At the time of autopsy, brain weights were within 2 SDs of the norm for age. Complete neuropathologic examination, including analysis of cortical neurons impregnated with the rapid Golgi method, failed to provide clues as to cause or the pathoanatomic substrate of autistic behavior in these cases.
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U2 - 10.1001/archneur.1980.00500610029003
DO - 10.1001/archneur.1980.00500610029003
M3 - Article
C2 - 7447762
AN - SCOPUS:0019205798
VL - 37
SP - 749
EP - 753
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 12
ER -