Auto-and allo-epitopes in DQ alloreactive antibodies

Anat R. Tambur*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Purpose of review Significant interest is now focused on deciphering human leukocyte antigen (HLA) epitopes and the utilization of this new knowledge to improve donor-recipient matching in transplantation. A recently introduced concept is the appearance of antibodies against what may be considered as self-epitopes, including the introduction of the 'nonself-self paradigm'. Recent findings Common practice in analyzing HLA-DQ antibodies have been to separate between antibodies against the a chain and antibodies against the b chain of the molecule. This is despite the fact that the two chains have to intertwine together to be expressed stably on the cell surface. We have previously provided evidence that this practice is false. We further provide evidence to refute the use of 'self-epitopes' as an immunologically feasible terminology by delineating the historic events leading to today's misconceptions. Summary The evidence we present supports the need for a change in current practices. HLA-DQ antigens and antibodies should be viewed as combined DQα/β complexes. This will have impact to assigning cPRA value, assigning acceptable and unacceptable antigens, and pave the way to a better understanding of true HLA epitopes as we strive to improve donor-recipient compatibility and minimize generation of denovo HLA antibodies.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalCurrent opinion in organ transplantation
Volume21
Issue number4
DOIs
StatePublished - Aug 1 2016

Keywords

  • HLA epitopes
  • HLA-DQ
  • HLA-eplets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

Fingerprint Dive into the research topics of 'Auto-and allo-epitopes in DQ alloreactive antibodies'. Together they form a unique fingerprint.

Cite this