Autoimmune hepatitis: A histological variant associated with prominent centrilobular necrosis

H. S. Te, G. Koukoulis, D. R. Ganger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisting of severe centrilobular necrosis demarcated by a thin rim of hepatitic reaction. In contrast, the portal tracts appeared almost normal. This histological appearance has not been associated with autoimmune hepatitis. This presentation and the histology may represent an early pattern of autoimmune injury to the liver.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
Issue number2
StatePublished - 1997


  • Autoimmunity
  • Chronic active hepatitis
  • Hepatitis
  • Histology

ASJC Scopus subject areas

  • Gastroenterology


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