Autologous hematopoietic stem cell transplantation for childhood autoimmune disease

Francesca Milanetti, Mario Abinun, Julio C. Voltarelli, Richard K. Burt*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) can be used in the management of patients with autoimmune disorders. Experience gained in adults has helped to better define the conditioning regimens required and appropriate selection of patients who are most likely to benefit from autologous HSCT. The field has been shifting toward the use of safer and less intense nonmyeloablative regimens used earlier in the disease course before patients accumulate extensive irreversible organ damage. This article reviews the experience of using autologous HSCT in treating the most common childhood autoimmune and rheumatic diseases, primarily juvenile idiopathic arthritis, systemic lupus erythematosus, and diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)239-271
Number of pages33
JournalPediatric Clinics of North America
Volume57
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • Autoimmune diseases
  • Hematopoietic transplant
  • Pediatric
  • Rheumatic diseases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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