TY - JOUR
T1 - Autologous hematopoietic stem cell transplantation for childhood autoimmune disease
AU - Milanetti, Francesca
AU - Abinun, Mario
AU - Voltarelli, Julio C.
AU - Burt, Richard K.
PY - 2010/2
Y1 - 2010/2
N2 - Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) can be used in the management of patients with autoimmune disorders. Experience gained in adults has helped to better define the conditioning regimens required and appropriate selection of patients who are most likely to benefit from autologous HSCT. The field has been shifting toward the use of safer and less intense nonmyeloablative regimens used earlier in the disease course before patients accumulate extensive irreversible organ damage. This article reviews the experience of using autologous HSCT in treating the most common childhood autoimmune and rheumatic diseases, primarily juvenile idiopathic arthritis, systemic lupus erythematosus, and diabetes mellitus.
AB - Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) can be used in the management of patients with autoimmune disorders. Experience gained in adults has helped to better define the conditioning regimens required and appropriate selection of patients who are most likely to benefit from autologous HSCT. The field has been shifting toward the use of safer and less intense nonmyeloablative regimens used earlier in the disease course before patients accumulate extensive irreversible organ damage. This article reviews the experience of using autologous HSCT in treating the most common childhood autoimmune and rheumatic diseases, primarily juvenile idiopathic arthritis, systemic lupus erythematosus, and diabetes mellitus.
KW - Autoimmune diseases
KW - Hematopoietic transplant
KW - Pediatric
KW - Rheumatic diseases
UR - http://www.scopus.com/inward/record.url?scp=77951049018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951049018&partnerID=8YFLogxK
U2 - 10.1016/j.pcl.2009.12.003
DO - 10.1016/j.pcl.2009.12.003
M3 - Review article
C2 - 20307720
AN - SCOPUS:77951049018
VL - 57
SP - 239
EP - 271
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
SN - 0031-3955
IS - 1
ER -