Autologous hematopoietic stem cell transplantation for type 1 diabetes

Júlio C. Voltarelli; Carlos E.B. Couri; Ana B.P.L. Stracieri; Maria C. Oliveira; Daniela A. Moraes; Fabiano Pieroni; George M.N. Barros; Maria Isabel A. Madeira; Kelen C.R. Malmegrim; Maria C. Foss-Freitas; Belinda P. Simões; Milton C. Foss; Elizabeth Squiers; Richard K. Burt

doi:10.1196/annals.1447.048

Autologous hematopoietic stem cell transplantation for type 1 diabetes

Júlio C. Voltarelli, Carlos E.B. Couri, Ana B.P.L. Stracieri, Maria C. Oliveira, Daniela A. Moraes, Fabiano Pieroni, George M.N. Barros, Maria Isabel A. Madeira, Kelen C.R. Malmegrim, Maria C. Foss-Freitas, Belinda P. Simões, Milton C. Foss, Elizabeth Squiers, Richard K. Burt

Medicine, Immunotherapy for Autoimmune Disease Division

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

35 Scopus citations

Abstract

In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.

Original language	English (US)
Title of host publication	Immunology of Diabetes V From Bench to Bedside
Publisher	Blackwell Publishing Inc.
Pages	220-229
Number of pages	10
ISBN (Print)	9781573317337
DOIs	https://doi.org/10.1196/annals.1447.048
State	Published - Dec 2008

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1150
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

High-dose immunosuppression
Stem cell transplantation
Type 1 diabetes

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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Voltarelli, J. C., Couri, C. E. B., Stracieri, A. B. P. L., Oliveira, M. C., Moraes, D. A., Pieroni, F., Barros, G. M. N., Madeira, M. I. A., Malmegrim, K. C. R., Foss-Freitas, M. C., Simões, B. P., Foss, M. C., Squiers, E., & Burt, R. K. (2008). Autologous hematopoietic stem cell transplantation for type 1 diabetes. In Immunology of Diabetes V From Bench to Bedside (pp. 220-229). (Annals of the New York Academy of Sciences; Vol. 1150). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1447.048

Voltarelli, Júlio C. ; Couri, Carlos E.B. ; Stracieri, Ana B.P.L. ; Oliveira, Maria C. ; Moraes, Daniela A. ; Pieroni, Fabiano ; Barros, George M.N. ; Madeira, Maria Isabel A. ; Malmegrim, Kelen C.R. ; Foss-Freitas, Maria C. ; Simões, Belinda P. ; Foss, Milton C. ; Squiers, Elizabeth ; Burt, Richard K. / Autologous hematopoietic stem cell transplantation for type 1 diabetes. Immunology of Diabetes V From Bench to Bedside. Blackwell Publishing Inc., 2008. pp. 220-229 (Annals of the New York Academy of Sciences).

@inproceedings{4ecda5e604374d779efecf022f0a03b5,

title = "Autologous hematopoietic stem cell transplantation for type 1 diabetes",

abstract = "In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeir{\~a}o Preto Medical School, University of S{\~a}o Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.",

keywords = "High-dose immunosuppression, Stem cell transplantation, Type 1 diabetes",

author = "Voltarelli, {J{\'u}lio C.} and Couri, {Carlos E.B.} and Stracieri, {Ana B.P.L.} and Oliveira, {Maria C.} and Moraes, {Daniela A.} and Fabiano Pieroni and Barros, {George M.N.} and Madeira, {Maria Isabel A.} and Malmegrim, {Kelen C.R.} and Foss-Freitas, {Maria C.} and Sim{\~o}es, {Belinda P.} and Foss, {Milton C.} and Elizabeth Squiers and Burt, {Richard K.}",

year = "2008",

month = dec,

doi = "10.1196/annals.1447.048",

language = "English (US)",

isbn = "9781573317337",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing Inc.",

pages = "220--229",

booktitle = "Immunology of Diabetes V From Bench to Bedside",

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Voltarelli, JC, Couri, CEB, Stracieri, ABPL, Oliveira, MC, Moraes, DA, Pieroni, F, Barros, GMN, Madeira, MIA, Malmegrim, KCR, Foss-Freitas, MC, Simões, BP, Foss, MC, Squiers, E & Burt, RK 2008, Autologous hematopoietic stem cell transplantation for type 1 diabetes. in Immunology of Diabetes V From Bench to Bedside. Annals of the New York Academy of Sciences, vol. 1150, Blackwell Publishing Inc., pp. 220-229. https://doi.org/10.1196/annals.1447.048

Autologous hematopoietic stem cell transplantation for type 1 diabetes. / Voltarelli, Júlio C.; Couri, Carlos E.B.; Stracieri, Ana B.P.L.; Oliveira, Maria C.; Moraes, Daniela A.; Pieroni, Fabiano; Barros, George M.N.; Madeira, Maria Isabel A.; Malmegrim, Kelen C.R.; Foss-Freitas, Maria C.; Simões, Belinda P.; Foss, Milton C.; Squiers, Elizabeth; Burt, Richard K.

Immunology of Diabetes V From Bench to Bedside. Blackwell Publishing Inc., 2008. p. 220-229 (Annals of the New York Academy of Sciences; Vol. 1150).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Voltarelli, Júlio C.

AU - Couri, Carlos E.B.

AU - Stracieri, Ana B.P.L.

AU - Oliveira, Maria C.

AU - Moraes, Daniela A.

AU - Pieroni, Fabiano

AU - Barros, George M.N.

AU - Madeira, Maria Isabel A.

AU - Malmegrim, Kelen C.R.

AU - Foss-Freitas, Maria C.

AU - Simões, Belinda P.

AU - Foss, Milton C.

AU - Squiers, Elizabeth

AU - Burt, Richard K.

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N2 - In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.

AB - In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.

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KW - Stem cell transplantation

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PB - Blackwell Publishing Inc.

ER -

Autologous hematopoietic stem cell transplantation for type 1 diabetes

Abstract

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Keywords

ASJC Scopus subject areas

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