Autologous hematopoietic stem cell transplantation for type 1 diabetes

Júlio C. Voltarelli, Carlos E.B. Couri, Ana B.P.L. Stracieri, Maria C. Oliveira, Daniela A. Moraes, Fabiano Pieroni, George M.N. Barros, Maria Isabel A. Madeira, Kelen C.R. Malmegrim, Maria C. Foss-Freitas, Belinda P. Simões, Milton C. Foss, Elizabeth Squiers, Richard K. Burt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Scopus citations

Abstract

In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.

Original languageEnglish (US)
Title of host publicationImmunology of Diabetes V From Bench to Bedside
PublisherBlackwell Publishing Inc.
Pages220-229
Number of pages10
ISBN (Print)9781573317337
DOIs
StatePublished - Dec 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1150
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • High-dose immunosuppression
  • Stem cell transplantation
  • Type 1 diabetes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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