TY - GEN
T1 - Autologous hematopoietic stem cell transplantation for type 1 diabetes
AU - Voltarelli, Júlio C.
AU - Couri, Carlos E.B.
AU - Stracieri, Ana B.P.L.
AU - Oliveira, Maria C.
AU - Moraes, Daniela A.
AU - Pieroni, Fabiano
AU - Barros, George M.N.
AU - Madeira, Maria Isabel A.
AU - Malmegrim, Kelen C.R.
AU - Foss-Freitas, Maria C.
AU - Simões, Belinda P.
AU - Foss, Milton C.
AU - Squiers, Elizabeth
AU - Burt, Richard K.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2008/12
Y1 - 2008/12
N2 - In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.
AB - In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.
KW - High-dose immunosuppression
KW - Stem cell transplantation
KW - Type 1 diabetes
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U2 - 10.1196/annals.1447.048
DO - 10.1196/annals.1447.048
M3 - Conference contribution
C2 - 19120300
AN - SCOPUS:57749175499
SN - 9781573317337
T3 - Annals of the New York Academy of Sciences
SP - 220
EP - 229
BT - Immunology of Diabetes V From Bench to Bedside
PB - Blackwell Publishing Inc.
ER -