Autologous vascular regeneration for peripheral artery disease with induced pluripotent stem cells

Bin Jiang*, Yunxiao Zhu, Xinlong Wang, Nancy Rivera Bolanos, Chongwen Duan, Xiaomin Zhang, Guillermo Ameer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Peripheral artery disease (PAD) affects 8.5 million and 200 million people in the United States and world-wide, respectively1. Many patients with critical limb ischemia (CLI) are ineligible for conventional revascularization procedures, having to face limb amputations or death.2 Transplantation of autologous stem cells may provide an alternative option for those patients by potentially regenerating vascular tissues and structures. However, acute cell death, uncontrollable differentiation, and low functional engraftment rate remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation and integration to host tissues may potentially transform the clinical outcome of stem-cell based regenerative therapies.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages446
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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