TY - GEN
T1 - Autologous vascular regeneration for peripheral artery disease with induced pluripotent stem cells
AU - Jiang, Bin
AU - Zhu, Yunxiao
AU - Wang, Xinlong
AU - Bolanos, Nancy Rivera
AU - Duan, Chongwen
AU - Zhang, Xiaomin
AU - Ameer, Guillermo
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Peripheral artery disease (PAD) affects 8.5 million and 200 million people in the United States and world-wide, respectively1. Many patients with critical limb ischemia (CLI) are ineligible for conventional revascularization procedures, having to face limb amputations or death.2 Transplantation of autologous stem cells may provide an alternative option for those patients by potentially regenerating vascular tissues and structures. However, acute cell death, uncontrollable differentiation, and low functional engraftment rate remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation and integration to host tissues may potentially transform the clinical outcome of stem-cell based regenerative therapies.
AB - Statement of Purpose: Peripheral artery disease (PAD) affects 8.5 million and 200 million people in the United States and world-wide, respectively1. Many patients with critical limb ischemia (CLI) are ineligible for conventional revascularization procedures, having to face limb amputations or death.2 Transplantation of autologous stem cells may provide an alternative option for those patients by potentially regenerating vascular tissues and structures. However, acute cell death, uncontrollable differentiation, and low functional engraftment rate remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation and integration to host tissues may potentially transform the clinical outcome of stem-cell based regenerative therapies.
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M3 - Conference contribution
AN - SCOPUS:85065439037
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 446
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -