Automated morphologic evaluation of pulmonary arteries in primary pulmonary hypertension

Lawrence M. Boxt*, Stuart Rich, Ruthellen Fried, Lizellen La Follette, Tamas Sandor, William B. Hanlon, Donald P. Harrington, Lynne Reid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Pulmonary wedge angiograms have been shown to reflect the severity of pulmonary vascular disease in congenital heart disease. Thirteen pulmonary wedge angiograms with a balloon occlusion catheter were performed in 11 adult patients (five normals and six with primary pulmonary hypertension [PPH]) and their features related to the resting pulmonary artery pressure (PAP). Individual cine frames from each study were selected and digitized with a computer-assisted operator-interactive program. By fitting densi- tometric profiles from the vessel segments, serial arterial cross- sectional diameters were calculated from mathematically derived points. There was a strong correlation between arterial taper (T, change in vessel caliber per unit axial length) and a power function of mean PAP with T = 0.304 × PAP = 0.59, R =.91, P<.001. These results demonstrate a correlation between an angiographically derived morphologic characteristic of the pulmonary vasculature (taper) and a hemodynamic parameter (PAP) in PPH. This offers a method to follow the course of the disease and the effects of drug therapy by assessing anatomic changes in the vessels.

Original languageEnglish (US)
Pages (from-to)906-909
Number of pages4
JournalInvestigative radiology
Issue number12
StatePublished - Dec 1986


  • Computer-assisted analysis
  • Primary pulmonary hypertension
  • Vascular morphology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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