TY - GEN
T1 - Automatic detection of drug interaction mismatches in package inserts
AU - Rastegar-Mojarad, Majid
AU - Harrington, Brian
AU - Belknap, Steven M.
PY - 2013
Y1 - 2013
N2 - The US Code of Federal Regulation (21 CFR 207) mandates that pharmaceutical manufacturers submit their FDA-approved drug information as medication Package Insert (PI). PI should provide comprehensive, current, and accurate information about the medical use of a drug. However, PI narratives are cumbersome for healthcare providers to navigate and are therefore rarely used by them. We are developing Paracelsus, a tool for automatically extracting structured drug information from PI. Paracelsus has the potential to allow healthcare providers to benefit from the rich drug information in PI for patient care. In this study, we report the development and evaluation of Paracelsus on drug-drug interactions. We show that Paracelsus performs with a high accuracy, discovering interactions not covered by other medical compendia, and in addition automatically detecting inconsistencies in the package inserts.
AB - The US Code of Federal Regulation (21 CFR 207) mandates that pharmaceutical manufacturers submit their FDA-approved drug information as medication Package Insert (PI). PI should provide comprehensive, current, and accurate information about the medical use of a drug. However, PI narratives are cumbersome for healthcare providers to navigate and are therefore rarely used by them. We are developing Paracelsus, a tool for automatically extracting structured drug information from PI. Paracelsus has the potential to allow healthcare providers to benefit from the rich drug information in PI for patient care. In this study, we report the development and evaluation of Paracelsus on drug-drug interactions. We show that Paracelsus performs with a high accuracy, discovering interactions not covered by other medical compendia, and in addition automatically detecting inconsistencies in the package inserts.
KW - Drug-Drug interaction
KW - Package Insert
KW - information retrival
UR - http://www.scopus.com/inward/record.url?scp=84891940560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891940560&partnerID=8YFLogxK
U2 - 10.1109/ICACCI.2013.6637200
DO - 10.1109/ICACCI.2013.6637200
M3 - Conference contribution
AN - SCOPUS:84891940560
SN - 9781467362153
T3 - Proceedings of the 2013 International Conference on Advances in Computing, Communications and Informatics, ICACCI 2013
SP - 373
EP - 377
BT - Proceedings of the 2013 International Conference on Advances in Computing, Communications and Informatics, ICACCI 2013
T2 - 2013 2nd International Conference on Advances in Computing, Communications and Informatics, ICACCI 2013
Y2 - 22 August 2013 through 25 August 2013
ER -