Automatic Memory Processes in Patients With Multiple Sclerosis

Jordan Grafman*, Stephen Rao, Linda Bernardin, Gary J. Leo

*Corresponding author for this work

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

To better understand the nature of the memory deficit in patients with multiple sclerosis, we designed a study to compare automatic vs effortful memory processes. Fortyone patients with definite multiple sclerosis and 45 demographically matched normal control subjects were administered two tasks designed to assess both automatic (monitoring frequency and modality) and effortful (free and cued-recall) processing. Results indicated that patients with multiple sclerosis, as expected, were significantly impaired on memory measures requiring effort, but performed normally on automatic measures. Performance on the memory indexes did not correlate with self-reported depression. The implications of these findings for delineating the locus of the memory impairment in multiple sclerosis is discussed.

Original languageEnglish (US)
Pages (from-to)1072-1075
Number of pages4
JournalArchives of Neurology
Volume48
Issue number10
DOIs
StatePublished - Oct 1991

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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