Autonomic Dysfunction and Neurohormonal Disorders in Atrial Fibrillation

Anna Pfenniger, Gail Elizabeth Geist, Rishi Arora*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Atrial fibrillation (AF) is the most commonly diagnosed arrhythmia and eludes an efficacious cure despite an increasing prevalence and a significant association with morbidity and mortality. In addition to an array of clinical sequelae, the origins and propagation of AF are multifactorial. In recent years, the contribution from the autonomic nervous system has been an area of particular interest. This review highlights the relevant physiology of autonomic and neurohormonal contributions to AF origin and maintenance, the current state of the literature on targeted therapies, and the path forward for clinical interventions.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCardiac Electrophysiology Clinics
Issue number1
StatePublished - Mar 2021


  • Atrial fibrillation
  • Autonomic modulation
  • Autonomic nervous system
  • Neurohormonal

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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