Autonomic Nervous System Dysfunction: JACC Focus Seminar

Jeffrey J. Goldberger, Rishi K Arora, Una Buckley, Kalyanam Shivkumar

Research output: Contribution to journalReview article

Abstract

Autonomic nervous system control of the heart is a dynamic process in both health and disease. A multilevel neural network is responsible for control of chronotropy, lusitropy, dromotropy, and inotropy. Intrinsic autonomic dysfunction arises from diseases that directly affect the autonomic nerves, such as diabetes mellitus and the syndromes of primary autonomic failure. Extrinsic autonomic dysfunction reflects the changes in autonomic function that are secondarily induced by cardiac or other disease. An array of tests interrogate various aspects of cardiac autonomic control in either resting conditions or with physiological perturbations from resting conditions. The prognostic significance of these assessments have been well established. Clinical usefulness has not been established, and the precise mechanistic link to mortality is less well established. Further efforts are required to develop optimal approaches to delineate cardiac autonomic dysfunction and its adverse effects to develop tools that can be used to guide clinical decision-making.

Original languageEnglish (US)
Pages (from-to)1189-1206
Number of pages18
JournalJournal of the American College of Cardiology
Volume73
Issue number10
DOIs
StatePublished - Mar 19 2019

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Autonomic Nervous System
Autonomic Pathways
Diabetes Mellitus
Mortality
Health

Keywords

  • arrhythmia
  • autonomic
  • heart failure
  • myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Goldberger, Jeffrey J. ; Arora, Rishi K ; Buckley, Una ; Shivkumar, Kalyanam. / Autonomic Nervous System Dysfunction : JACC Focus Seminar. In: Journal of the American College of Cardiology. 2019 ; Vol. 73, No. 10. pp. 1189-1206.
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Autonomic Nervous System Dysfunction : JACC Focus Seminar. / Goldberger, Jeffrey J.; Arora, Rishi K; Buckley, Una; Shivkumar, Kalyanam.

In: Journal of the American College of Cardiology, Vol. 73, No. 10, 19.03.2019, p. 1189-1206.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Autonomic Nervous System Dysfunction

T2 - JACC Focus Seminar

AU - Goldberger, Jeffrey J.

AU - Arora, Rishi K

AU - Buckley, Una

AU - Shivkumar, Kalyanam

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