Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells

Prianka H. Hashim; Madeline J. Perry; Michele T. Pritchard; Jennifer L. Gerton; Francesca E. Duncan

doi:10.1530/REP-25-0042

Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells

Prianka H. Hashim, Madeline J. Perry, Michele T. Pritchard, Jennifer L. Gerton, Francesca E. Duncan^*

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

Abstract

We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.

Original language	English (US)
Article number	e250042
Journal	Reproduction
Volume	169
Issue number	5
DOIs	https://doi.org/10.1530/REP-25-0042
State	Published - May 2025

Funding

This work was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development (R01HD105752) to JLG and FED.

Keywords

follicle
granulosa cells
immune signaling
surveillance

ASJC Scopus subject areas

Reproductive Medicine
Embryology
Endocrinology
Obstetrics and Gynecology
Cell Biology

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10.1530/REP-25-0042

Cite this

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title = "Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells",

abstract = "We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.",

keywords = "follicle, granulosa cells, immune signaling, surveillance",

author = "Hashim, {Prianka H.} and Perry, {Madeline J.} and Pritchard, {Michele T.} and Gerton, {Jennifer L.} and Duncan, {Francesca E.}",

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AU - Pritchard, Michele T.

AU - Gerton, Jennifer L.

AU - Duncan, Francesca E.

PY - 2025/5

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AB - We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.

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KW - immune signaling

KW - surveillance

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Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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