Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves

Huan Meng*, Min Xue, Tian Xia, Yan Li Zhao, Fuyuhiko Tamanoi, J. Fraser Stoddart, Jeffrey I. Zink, Andre E. Nel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

478 Scopus citations

Abstract

Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of β-cyclodextrin (β-CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB-31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells.

Original languageEnglish (US)
Pages (from-to)12690-12697
Number of pages8
JournalJournal of the American Chemical Society
Volume132
Issue number36
DOIs
StatePublished - Sep 15 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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