Autonomous pacemakers in the basal ganglia: Who needs excitatory synapses anyway?

D. James Surmeier; Jeff N. Mercer; C. Savio Chan

doi:10.1016/j.conb.2005.05.007

Autonomous pacemakers in the basal ganglia: Who needs excitatory synapses anyway?

D. James Surmeier^*, Jeff N. Mercer, C. Savio Chan

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

Autonomous pacemakers are crucial elements in many neural circuits. This is particularly true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast- and slow-spiking pacemakers. Our understanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yielding new insights into the normal functioning of this network and how it goes awry in pathological states such as Parkinson's disease.

Original language	English (US)
Pages (from-to)	312-318
Number of pages	7
Journal	Current opinion in neurobiology
Volume	15
Issue number	3 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.conb.2005.05.007
State	Published - Jun 2005

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2005.05.007

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title = "Autonomous pacemakers in the basal ganglia: Who needs excitatory synapses anyway?",

abstract = "Autonomous pacemakers are crucial elements in many neural circuits. This is particularly true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast- and slow-spiking pacemakers. Our understanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yielding new insights into the normal functioning of this network and how it goes awry in pathological states such as Parkinson's disease.",

author = "Surmeier, {D. James} and Mercer, {Jeff N.} and Chan, {C. Savio}",

note = "Funding Information: NIH NINDS awards NS 34696, NS 047085 and a Picower Foundation grant supported this work.",

year = "2005",

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T2 - Who needs excitatory synapses anyway?

AU - Surmeier, D. James

AU - Mercer, Jeff N.

AU - Chan, C. Savio

N1 - Funding Information: NIH NINDS awards NS 34696, NS 047085 and a Picower Foundation grant supported this work.

PY - 2005/6

Y1 - 2005/6

N2 - Autonomous pacemakers are crucial elements in many neural circuits. This is particularly true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast- and slow-spiking pacemakers. Our understanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yielding new insights into the normal functioning of this network and how it goes awry in pathological states such as Parkinson's disease.

AB - Autonomous pacemakers are crucial elements in many neural circuits. This is particularly true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast- and slow-spiking pacemakers. Our understanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yielding new insights into the normal functioning of this network and how it goes awry in pathological states such as Parkinson's disease.

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U2 - 10.1016/j.conb.2005.05.007

DO - 10.1016/j.conb.2005.05.007

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AN - SCOPUS:20444411546

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JO - Current opinion in neurobiology

JF - Current opinion in neurobiology

IS - 3 SPEC. ISS.

ER -

Autonomous pacemakers in the basal ganglia: Who needs excitatory synapses anyway?

Abstract

ASJC Scopus subject areas

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