Autonomous pacemakers in the basal ganglia: Who needs excitatory synapses anyway?

D. James Surmeier*, Jeff N. Mercer, C. Savio Chan

*Corresponding author for this work

Research output: Contribution to journalReview article

80 Scopus citations

Abstract

Autonomous pacemakers are crucial elements in many neural circuits. This is particularly true for the basal ganglia. This richly interconnected group of nuclei is rife with both fast- and slow-spiking pacemakers. Our understanding of the ionic mechanisms underlying pacemaking in these neurons is rapidly evolving, yielding new insights into the normal functioning of this network and how it goes awry in pathological states such as Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalCurrent opinion in neurobiology
Volume15
Issue number3 SPEC. ISS.
DOIs
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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