Autophagy and macropinocytosis: Keeping an eye on the corneal/limbal epithelia

Han Peng, Jong Kook Park, Robert M. Lavker*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively understudied in these two epithelia. In this Perspectives, we describe the basic principles behind macropinocytosis and autophagy, discuss how these two processes are regulated in the limbal and corneal epithelia, consider how these two processes impact on the physiology of limbal and corneal epithelia, and elaborate on areas of future research in autophagy and macropinocytosis as related to the limbal/corneal epithelia.

Original languageEnglish (US)
Pages (from-to)416-423
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Autophagy
  • Corneal epithelium
  • Limbal epithelium
  • Macropinocytosis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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