Abstract
Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-213 |
| Number of pages | 3 |
| Journal | ACS chemical biology |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 23 2006 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine