Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

Timothy M. Hall; Marie Pier Tétreault; Kathryn E. Hamilton; Kelly A. Whelan

doi:10.1016/j.coph.2018.04.003

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

Timothy M. Hall, Marie Pier Tétreault, Kathryn E. Hamilton, Kelly A. Whelan

Medicine, Gastroenterology Division

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.

Original language	English (US)
Pages (from-to)	12-19
Number of pages	8
Journal	Current Opinion in Pharmacology
Volume	41
DOIs	https://doi.org/10.1016/j.coph.2018.04.003
State	Published - Aug 2018

Funding

This study was supported by the following NIH Grants: K01DK103953 (KAW), R00DK094977 (MPT), R01DK116988 (MPT), K01DK100485 (KEH), R03DK114463 (KEH) and a Zell Scholarship from the Robert H. Lurie Comprehensive Cancer Center (MPT) .

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma",

abstract = "Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.",

author = "Hall, {Timothy M.} and T{\'e}treault, {Marie Pier} and Hamilton, {Kathryn E.} and Whelan, {Kelly A.}",

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doi = "10.1016/j.coph.2018.04.003",

language = "English (US)",

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T1 - Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

AU - Hall, Timothy M.

AU - Tétreault, Marie Pier

AU - Hamilton, Kathryn E.

AU - Whelan, Kelly A.

PY - 2018/8

Y1 - 2018/8

N2 - Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.

AB - Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.

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JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma

Abstract

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ASJC Scopus subject areas

UN SDGs

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