Axial ligand effects: Utilization of chiral sulfoxide additives for the induction of asymmetry in (Salen)ruthenium(II) olefin cyclopropanation catalysts

Jason A. Miller*, Bradley A. Gross, Michael A. Zhuravel, Wiechang Jin, Son Binh T. Nguyen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

An efficient and facile method is used to develop new (salen)ruthenium(II) catalysts for the asymmetric cyclopropanation of olefins, in which a chiral additive induces asymmetry in inexpensive and readily synthesized achiral (salen)ruthenium(II) catalysts (see scheme; EDA = ethyl diazoacetate). This approach is amenable to parallel-screening optimization and has great potential advantages over traditional catalyst development and synthetic methods. (Chemical Equation Presented)

Original languageEnglish (US)
Pages (from-to)3885-3889
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number25
DOIs
StatePublished - Jun 20 2005

Keywords

  • Cyclopropanation
  • Ligand-accelerated catalysis
  • Ruthenium
  • Salen
  • Sulfoxides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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