Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes

Hayden A. Sharma, M. Todd Hovey, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

Original languageEnglish (US)
Pages (from-to)9283-9286
Number of pages4
JournalChemical Communications
Issue number59
StatePublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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