B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas

Dharma R. Thapa, Kishor Bhatia, Jay H. Bream, Gypsyamber D'Souza, Charles R. Rinaldo, Steven Wolinsky, Roger Detels, Otoniel Martínez-Maza*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n = 13, <3 years prior to diagnosis) when compared with HIV-negative (n = 18) or HIV-positive controls (n = 21) (P < 0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD4 +0 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.

Original languageEnglish (US)
Pages (from-to)1177-1180
Number of pages4
JournalAIDS
Volume26
Issue number9
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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