B-Cells and Antibody-Mediated Pathogenesis in Chronic Rhinosinusitis with Nasal Polyps

Jin Young Min, Kathryn E Hulse, Bruce Kuang-Huay Tan*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The sinonasal mucosa forms a dynamic immune barrier where epithelial cells and the immune system interact with the inhaled environment and nasal microbiome. Recent studies suggest that B-cells, plasma cells and antibody production are highly activated locally within the nasal mucosa of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Findings additionally suggest that polyp tissue contains elevated levels of cytokines, chemokines and complement that may drive this profound B-cell response. Currently, the data are conflicting on whether the B-cell response found in the CRSwNP nasal mucosa is antigen-specific, a superantigen response or an expansion of natural antibody responses. Indeed, investigations into the specificity of the mucosal antibody responses find increased production of class-switched antibodies that bind to aeroallergens, staphylococcus aureus as well as autoantigens. A continuation of these studies is needed to elucidate whether extrinsic factors, like the inhaled environment, or intrinsic factors, like the mucosal microbiome and host inflammatory response, are key to the pathogenesis of CRSwNP. This chapter will cover the current evidence regarding local B-cell responses in CRSwNP.

Original languageEnglish (US)
Pages (from-to)48-57
Number of pages10
JournalAdvances in Oto-Rhino-Laryngology
Volume79
DOIs
StatePublished - Jan 1 2016

Fingerprint

Nasal Polyps
B-Lymphocytes
Antibody Formation
Nasal Mucosa
Antibodies
Microbiota
Superantigens
Intrinsic Factor
Immunoglobulin Isotypes
Autoantigens
Polyps
Plasma Cells
Nose
Chemokines
Staphylococcus aureus
Immune System
Mucous Membrane
Epithelial Cells
Cytokines
Antigens

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

@article{1ab1cea91d5247159641dcc98190018f,
title = "B-Cells and Antibody-Mediated Pathogenesis in Chronic Rhinosinusitis with Nasal Polyps",
abstract = "The sinonasal mucosa forms a dynamic immune barrier where epithelial cells and the immune system interact with the inhaled environment and nasal microbiome. Recent studies suggest that B-cells, plasma cells and antibody production are highly activated locally within the nasal mucosa of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Findings additionally suggest that polyp tissue contains elevated levels of cytokines, chemokines and complement that may drive this profound B-cell response. Currently, the data are conflicting on whether the B-cell response found in the CRSwNP nasal mucosa is antigen-specific, a superantigen response or an expansion of natural antibody responses. Indeed, investigations into the specificity of the mucosal antibody responses find increased production of class-switched antibodies that bind to aeroallergens, staphylococcus aureus as well as autoantigens. A continuation of these studies is needed to elucidate whether extrinsic factors, like the inhaled environment, or intrinsic factors, like the mucosal microbiome and host inflammatory response, are key to the pathogenesis of CRSwNP. This chapter will cover the current evidence regarding local B-cell responses in CRSwNP.",
author = "Min, {Jin Young} and Hulse, {Kathryn E} and Tan, {Bruce Kuang-Huay}",
year = "2016",
month = "1",
day = "1",
doi = "10.1159/000445129",
language = "English (US)",
volume = "79",
pages = "48--57",
journal = "Advances in Oto-Rhino-Laryngology",
issn = "0065-3071",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - B-Cells and Antibody-Mediated Pathogenesis in Chronic Rhinosinusitis with Nasal Polyps

AU - Min, Jin Young

AU - Hulse, Kathryn E

AU - Tan, Bruce Kuang-Huay

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The sinonasal mucosa forms a dynamic immune barrier where epithelial cells and the immune system interact with the inhaled environment and nasal microbiome. Recent studies suggest that B-cells, plasma cells and antibody production are highly activated locally within the nasal mucosa of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Findings additionally suggest that polyp tissue contains elevated levels of cytokines, chemokines and complement that may drive this profound B-cell response. Currently, the data are conflicting on whether the B-cell response found in the CRSwNP nasal mucosa is antigen-specific, a superantigen response or an expansion of natural antibody responses. Indeed, investigations into the specificity of the mucosal antibody responses find increased production of class-switched antibodies that bind to aeroallergens, staphylococcus aureus as well as autoantigens. A continuation of these studies is needed to elucidate whether extrinsic factors, like the inhaled environment, or intrinsic factors, like the mucosal microbiome and host inflammatory response, are key to the pathogenesis of CRSwNP. This chapter will cover the current evidence regarding local B-cell responses in CRSwNP.

AB - The sinonasal mucosa forms a dynamic immune barrier where epithelial cells and the immune system interact with the inhaled environment and nasal microbiome. Recent studies suggest that B-cells, plasma cells and antibody production are highly activated locally within the nasal mucosa of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Findings additionally suggest that polyp tissue contains elevated levels of cytokines, chemokines and complement that may drive this profound B-cell response. Currently, the data are conflicting on whether the B-cell response found in the CRSwNP nasal mucosa is antigen-specific, a superantigen response or an expansion of natural antibody responses. Indeed, investigations into the specificity of the mucosal antibody responses find increased production of class-switched antibodies that bind to aeroallergens, staphylococcus aureus as well as autoantigens. A continuation of these studies is needed to elucidate whether extrinsic factors, like the inhaled environment, or intrinsic factors, like the mucosal microbiome and host inflammatory response, are key to the pathogenesis of CRSwNP. This chapter will cover the current evidence regarding local B-cell responses in CRSwNP.

UR - http://www.scopus.com/inward/record.url?scp=84992107969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992107969&partnerID=8YFLogxK

U2 - 10.1159/000445129

DO - 10.1159/000445129

M3 - Article

VL - 79

SP - 48

EP - 57

JO - Advances in Oto-Rhino-Laryngology

JF - Advances in Oto-Rhino-Laryngology

SN - 0065-3071

ER -