B Cells and Regulatory B Cells in Cancer Escape

Arya Biragyn*, Catalina Lee Chang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In order to evade antitumor effector immune cells and metastasize, cancer often employs a diverse group of immune cells with suppressive and immunomodulatory functions. In this process, the role of regulatory B cells (Bregs) remains poorly understood despite their ability to modulate immune responses. The search for Bregs is complicated by the complexity of cancer, lack of unique markers, and functional overlap with B cells expressing suppressive factors. To date, cancer is shown to generate at least two types of Bregs, including tumor-evoked (t)Bregs and granzyme (GrB)+Bregs, although it may also use other Bregs that protect from autoimmunity.

Original languageEnglish (US)
Title of host publicationImmunity to Pathogens and Tumors
PublisherElsevier Inc.
Pages470-486
Number of pages17
Volume4
ISBN (Print)9780080921525
DOIs
StatePublished - Apr 27 2016

Keywords

  • Antitumor immunity
  • B cell
  • Bregs
  • Cancer
  • GrBBregs
  • TBregs

ASJC Scopus subject areas

  • Medicine(all)

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